Renal papillary necrosis and pyelonephritis accompanying fenoprofen therapy

doi:10.1001/jama.242.17.1896

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Vol. 242 No. 17, October 26, 1979

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Renal papillary necrosis and pyelonephritis accompanying fenoprofen therapy

F. E. Husserl, R. K. Lange and C. M. Kantrow Jr

Renal papillary necrosis occurred after fenoprofen calcium administration in a patient with systemic lupus erythematosus and urinary tract infection. Possible mechanisms of renal damage may be hypersensitivity, decreased blood flow, and decreased production of a prostaglandin E-like substance.

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