This Article  • References  • Full text PDF  • Correction  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Studies on Survival

Carlos E. Ruiz, MD, PhD; Max Harry Weil, MD, PhD; Richard W. Carlson, MD, PhD

JAMA. 1979;242(2):165-168.

Abstract
Therapeutic effects of dopamine hydrochloride on the peripheral and metabolic defects of shock were investigated in 34 patients with circulatory shock associated with myocardial infarction, bacteremia, or hypovolemia. Severity of the circulatory defect characterized by hypotension, reduced cardiac output, oliguria, and notably reduced skin (toe) temperature before treatment with dopamine was not directly related to survival. However, the arterial blood concentration of lactate before treatment with dopamine indicated the likelihood of survival. Patients who ultimately survived following treatment with dopamine had normal or only mildly elevated levels of arterial blood lactate before therapy. No patients with established shock states in whom perfusion failure was associated with substantial increases in the level of arterial blood lactate survived regardless of treatment with dopamine. Increases in toe temperature during dopamine treatment also emerged as a uniquely good indicator of favorable outcome during therapy.

(JAMA 242:165-168, 1979)

Author Affiliations
From the Shock Research Unit and the Institute of Critical Care Medicine, University of Southern California School of Medicine, Los Angeles; The Los Angeles County /University of Southern California Medical Center; and the Center for the Critically III, Hollywood Presbyterian Medical Center, Los Angeles.

Footnotes
Reprint requests to Institute of Critical Care Medicine, University of Southern California School of Medicine, 1300 N Vermont Ave, Los Angeles, CA 90027 (Dr Weil).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Core-peripheral temperature gradient as a diagnostic test in dyspnoea
Clarke et al.
Emerg. Med. J. 2005;22:633-635.
ABSTRACT | FULL TEXT  

Dysoxia and lactate
Duke
Arch. Dis. Child. 1999;81:343-350.
FULL TEXT