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Harold L. Newmark, MS; Jacob M. Scheiner, MS; Martin Marcus, MS; Makund Prabhudesai, MD

JAMA. 1979;242(21):2319-2320.

Abstract
Using extraction procedures in which the extracted vitamin B₁₂ was protected by cyanide or metabisulfite, several investigators found no change in vitamin B₁₂ when meals were incubated in the presence of ascorbic acid for 30 minutes at 37 °C. A previous report suggested degradation of vitamin B₁₂ under these conditions, but this was apparently caused by incomplete protection of the extracted vitamin B₁₂ in the assay procedure. If incubation at 37 °C for 30 minutes is a laboratory mimic of the gastric environment, one must conclude that high doses of ascorbic acid do not affect the stability of vitamin B₁₂ in vivo.

(JAMA 242:2319-2320, 1979)

Author Affiliations
From Hoffmann-La Roche Inc, Nutley, NJ (Messrs Newmark and Scheiner), and Lincoln Medical Center, Bronx, NY (Mr Marcus and Dr Prabhudesai).

Footnotes
Reprint requests to Food and Agricultural Products, Development Department, Hoffmann-La Roche Inc, Nutley, NJ 07110 (Mr Newmark).

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