You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT JAMA
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 242 No. 23, December 7, 1979 TABLE OF CONTENTS
  JAMA
  •  Online Features
  ARTICLE
 This Article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in JAMA

Five-year findings of the hypertension detection and follow-up program. I. Reduction in mortality of persons with high blood pressure, including mild hypertension. Hypertension Detection and Follow-up Program Cooperative Group


The Hypertension Detection and Follow-up Program (HDFP), in a community-based, randomized controlled trial involving 10,940 persons with high blood pressure (BP), compared the effects on five-year mortality of a systematic antihypertensive treatment program (Stepped Care [SC]) and referral to community medical therapy (Referred Care [RC]). Participants, recruited by population-based screening of 158,906 people aged 30 to 69 years in 14 communities througout the United States, were randomly assigned to SC or RC groups within each center and by entry diastolic blood pressure (DBP) (90 to 104, 105 to 114, and 115 + mm Hg). Over the five years of the study, more than two thirds of the SC participants continued to receive medication, and more than 50% achieved BP levels within the normotensive range, at or below the HDFP goal for DBP. Controls of BP was consistently better for the SC than for the RC group. Five-year mortality from all causes was 17% lower for the SC group compared to the RC group (6.4 vs 7.7 per 100, P less than .01) and 20% lower for the SC subgroup with entry DBP of 90 to 104 mm Hg compared to the corresponding RC subgroup (5.9 vs 7.4 per 100, P less than .01). These findings of the HDFP indicate that the systematic effective management of hypertension has a great potential for reducing mortality for the large numbers of people with high BP in the population, including those with "mild" hypertension.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Risk factors for non-fatal myocardial infarction and cardiac death in incident dialysis patients
Trivedi et al.
Nephrol Dial Transplant 2008;0:gfn426v1-gfn426.
ABSTRACT | FULL TEXT  

Thiazide-Type Diuretics and {beta}-Adrenergic Blockers as First-Line Drug Treatments for Hypertension
Cutler and Davis
Circulation 2008;117:2691-2705.
FULL TEXT  

Unintended Consequences of Resource-Based Relative Value Scale Reimbursement
Goodson
JAMA 2007;298:2308-2310.
FULL TEXT  

A Family Medicine Training Program in the Republic of Georgia: Incorporating a Model of Chronic Disease Management
Sanders
J Am Board Fam Med 2007;20:557-564.
ABSTRACT | FULL TEXT  

On-Treatment Diastolic Blood Pressure and Prognosis in Systolic Hypertension
Fagard et al.
Arch Intern Med 2007;167:1884-1891.
ABSTRACT | FULL TEXT  

Serum Uric Acid Level and Risk for Peripheral Arterial Disease: Analysis of Data From the Multiple Risk Factor Intervention Trial
Baker et al.
ANGIOLOGY 2007;58:450-457.
ABSTRACT  

Blood Pressure Reduction Is Not the Only Determinant of Outcome
Sever et al.
Circulation 2006;113:2754-2774.
FULL TEXT  

Comparative Antihypertensive Effects of Hydrochlorothiazide and Chlorthalidone on Ambulatory and Office Blood Pressure
Ernst et al.
Hypertension 2006;47:352-358.
ABSTRACT | FULL TEXT  

Changing Relationship of Blood Pressure with Mortality over Time among Hemodialysis Patients
Stidley et al.
J. Am. Soc. Nephrol. 2006;17:513-520.
ABSTRACT | FULL TEXT  

Efficacy of antihypertensive treatment: which endpoints should be considered?
Mancia and Grassi
Nephrol Dial Transplant 2005;20:2301-2303.
FULL TEXT  

ASCOT a Four Horse Race
Sever
Journal of Renin-Angiotensin-Aldosterone System 2005;6:51-54.
 

Systolic and Diastolic Blood Pressure Lowering as Determinants of Cardiovascular Outcome
Wang et al.
Hypertension 2005;45:907-913.
ABSTRACT | FULL TEXT  

Diuretics Are Color Blind
Neaton and Kuller
JAMA 2005;293:1663-1666.
FULL TEXT  

Incubation period of coronary heart disease
Rose
Int J Epidemiol 2005;34:242-244.
ABSTRACT | FULL TEXT  

General Practitioners' Approach to Hypertension in Urban Pakistan: Disturbing Trends in Practice
Jafar et al.
Circulation 2005;111:1278-1283.
ABSTRACT | FULL TEXT  

Children in South Asia Have Higher Body Mass-Adjusted Blood Pressure Levels Than White Children in the United States: A Comparative Study
Jafar et al.
Circulation 2005;111:1291-1297.
ABSTRACT | FULL TEXT  

Association Between Cardiovascular Outcomes and Antihypertensive Drug Treatment in Older Women
Wassertheil-Smoller et al.
JAMA 2004;292:2849-2859.
ABSTRACT | FULL TEXT  

ALLHAT: Setting the Record Straight
Davis et al.
ANN INTERN MED 2004;141:39-46.
ABSTRACT | FULL TEXT  

Blood Pressure and Stroke: An Overview of Published Reviews
Lawes et al.
Stroke 2004;35:1024-1033.
ABSTRACT | FULL TEXT  

Blood Pressure and Stroke: An Overview of Published Reviews
Lawes et al.
Stroke 2004;0:01.STR.0000126208.14181.D-1033.
ABSTRACT | FULL TEXT  

Blood Pressure and Stroke: An Overview of Published Reviews
Lawes et al.
Stroke 2004;35:776-785.
ABSTRACT | FULL TEXT  

Hydrochlorothiazide Versus Chlorthalidone: Evidence Supporting Their Interchangeability
Carter et al.
Hypertension 2004;43:4-9.
ABSTRACT | FULL TEXT  

Blood Pressure Reduction and Secondary Prevention of Stroke and Other Vascular Events: A Systematic Review
Rashid et al.
Stroke 2003;34:2741-2748.
ABSTRACT | FULL TEXT  

ABPM Is Valuable for the Management of Hypertension
Krakoff et al.
Arch Intern Med 2002;162:1528-1530.
FULL TEXT  

Caffeine Affects Cardiovascular and Neuroendocrine Activation at Work and Home
Lane et al.
Psychosom. Med. 2002;64:595-603.
ABSTRACT | FULL TEXT  

Isolated Systolic Hypertension Is Associated with Adverse Outcomes from Coronary Artery Bypass Grafting Surgery
Aronson et al.
Anesth. Analg. 2002;94:1079-1084.
ABSTRACT | FULL TEXT  

Association Between Pulse Pressure and Mortality in Patients Undergoing Maintenance Hemodialysis
Klassen et al.
JAMA 2002;287:1548-1555.
ABSTRACT | FULL TEXT  

J-Shaped Relationship between Blood Pressure and Mortality in Hypertensive Patients: New Insights from a Meta-Analysis of Individual-Patient Data
Boutitie et al.
ANN INTERN MED 2002;136:438-448.
ABSTRACT | FULL TEXT  

White-Coat Hypertension--To Treat or Not to Treat: A Clinical Dilemma
Moser
Arch Intern Med 2001;161:2655-2656.
FULL TEXT  

Commentary: Can health outputs of routine practice approach those of clinical trials?
Hart
Int J Epidemiol 2001;30:1263-1267.
FULL TEXT  

A score for predicting risk of death from cardiovascular disease in adults with raised blood pressure, based on individual patient data from randomised controlled trials
Pocock et al.
BMJ 2001;323:75-81.
ABSTRACT | FULL TEXT  

Baseline Characteristics of the Diabetic Participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
Barzilay et al.
Diabetes Care 2001;24:654-658.
ABSTRACT | FULL TEXT  

The Effects of a Collaborative Model of Primary Care on the Mortality and Hospital Use of Community-Dwelling Older Adults
Schraeder et al.
J. Gerontol. A Biol. Sci. Med. Sci. 2001;56:106M-112.
ABSTRACT | FULL TEXT  

Hypertension and Its Treatment in Postmenopausal Women : Baseline Data from the Women's Health Initiative
Wassertheil-Smoller et al.
Hypertension 2000;36:780-789.
ABSTRACT | FULL TEXT  

The Urgent Need to Improve Hypertension Care
Trilling and Froom
Arch Fam Med 2000;9:794-801.
ABSTRACT | FULL TEXT  

Perspectives on Isolated Systolic Hypertension in Elderly Patients
Vardan and Mookherjee
Arch Fam Med 2000;9:319-323.
ABSTRACT | FULL TEXT  

Reducing Antihypertensive Medication Use in Nursing Home Patients
Froom and Trilling
Arch Fam Med 2000;9:378-383.
ABSTRACT | FULL TEXT  

Chinese Trial on Isolated Systolic Hypertension in the Elderly
Wang et al.
Arch Intern Med 2000;160:211-220.
ABSTRACT | FULL TEXT  

Identification of Risk Factors in Hypertensive Patients : Contribution of Randomized Controlled Trials Through an Individual Patient Database
Gueyffier et al.
Circulation 1999;100 :e88-e94.
ABSTRACT | FULL TEXT  

Risk Mechanisms in Hypertensive Heart Disease
Frohlich
Hypertension 1999;34:782-789.
ABSTRACT | FULL TEXT  

Withholding treatment in white-coat hypertension: wishful thinking
Spence
CMAJ 1999;161:275-276.
FULL TEXT  

National Recommendations for the Pharmacological Treatment of Hypertension: Should They Be Revised?
Moser
Arch Intern Med 1999;159:1403-1406.
FULL TEXT  

Systematic review of antihypertensive therapies: Does the evidence assist in choosing a first-line drug?
Wright et al.
CMAJ 1999;161:25-32.
ABSTRACT | FULL TEXT  

Blood Pressure and the Progression of Carotid Atherosclerosis in Middle-Aged Men
Lakka et al.
Hypertension 1999;34:51-56.
ABSTRACT | FULL TEXT  

National Trends in the Management of Cardiovascular Disease Risk Factors in Children: Second NHLBI Survey of Primary Care Physicians
Kimm et al.
Pediatrics 1998;102:50e-50.
ABSTRACT | FULL TEXT  

Number needed to screen: development of a statistic for disease screening
Rembold
BMJ 1998;317:307-312.
ABSTRACT | FULL TEXT  

Effects of a Long-term Hypertension Control Program on Stroke Incidence and Prevalence in a Rural Community in Northeastern Japan
Iso et al.
Stroke 1998;29:1510-1518.
ABSTRACT | FULL TEXT  

New Targeted AHA Research Program : Cardiovascular Care and Outcomes
Hill
Circulation 1998;97:1221-1222.
FULL TEXT  

Behavior and Biology: The Basic Sciences for AHA Action : Presented at the 70th Scientific Sessions of the American Heart Association November 9, 1997 Orlando, Florida
Hill
Circulation 1998;97:807-810.
FULL TEXT  

Behavior and Biology: The Basic Sciences for AHA Action : Presented at the 70th Scientific Sessions of the American Heart Association November 9, 1997 Orlando, Florida
Hill
Stroke 1998;29:739-742.
FULL TEXT  

Hypertension treatment and control in sub-Saharan Africa: the epidemiological basis for policy
Cooper et al.
BMJ 1998;316:614-617.
FULL TEXT  

Effect of Antihypertensive Treatment in Patients Having Already Suffered From Stroke : Gathering the Evidence
Gueyffier et al.
Stroke 1997;28:2557-2562.
ABSTRACT | FULL TEXT  

Fish Consumption and the 30-Year Risk of Fatal Myocardial Infarction
Daviglus et al.
NEJM 1997;336:1046-1053.
ABSTRACT | FULL TEXT  

Nutrient Intake and Blood Pressure in the Dietary Intervention Study in Children
Simons-Morton et al.
Hypertension 1997;29:930-936.
ABSTRACT | FULL TEXT  

The Multilevel Compliance Challenge: Recommendations for a Call to Action: A Statement for Healthcare Professionals
Miller et al.
Circulation 1997;95:1085-1090.
FULL TEXT  

Combined Effects of Hypertension and Hypercholesterolemia on Radial Artery Function
Giannattasio et al.
Hypertension 1997;29:583-586.
ABSTRACT | FULL TEXT  

Different Concepts in First-Line Treatment of Essential Hypertension: Comparison of a Low-Dose Reserpine-Thiazide Combination With Nitrendipine Monotherapy
Kronig et al.
Hypertension 1997;29:651-658.
ABSTRACT | FULL TEXT  

Association of Chronic Stress With Plasminogen Activator Inhibitor–1 in Healthy Middle-aged Men
Raikkonen et al.
Arterioscler. Thromb. Vasc. Bio. 1996;16:363-367.
ABSTRACT | FULL TEXT  

Compliance Enhancement : A Call for Multidisciplinary Team Approaches
Hill and Houston Miller
Circulation 1996;93:4-6.
FULL TEXT  

Design issues in cohort studies
Prentice
Stat Methods Med Res 1995;4:273-292.
ABSTRACT  

Effects of Regular Exercise on Blood Pressure and Left Ventricular Hypertrophy in African-American Men with Severe Hypertension
Kokkinos et al.
NEJM 1995;333:1462-1467.
ABSTRACT | FULL TEXT  

Discontinuation of and changes in treatment after start of new courses of antihypertensive drugs: a study of a United Kingdom population
Jones et al.
BMJ 1995;311:293-295.
ABSTRACT | FULL TEXT  

Communicating the Benefits of Chronic Preventive Therapy: Does the Format of Efficacy Data Determine Patients' Acceptance of Treatment?
Hux and Naylor
Med Decis Making 1995;15:152-157.
ABSTRACT  

Trends in Medication Choices for Hypertension in the Elderly : The Decline of the Thiazides
Monane et al.
Hypertension 1995;25:1045-1051.
ABSTRACT | FULL TEXT  

The Impact of Age on the Cost - Effectiveness of Hypertension Treatment: An Analysis of Randomized Drug Trials
Johannesson
Med Decis Making 1994;14:236-244.
ABSTRACT  

Control of blood pressure and risk of first acute myocardial infarction: Skaraborg hypertension project
Lindblad et al.
BMJ 1994;308:681-685.
ABSTRACT | FULL TEXT  

The Impact of Increasing Intensity of Health Promotion Intervention on Risk Reduction
Shi
Eval Health Prof 1992;15:3-25.
ABSTRACT  

Effects of Nifedipine GITS and Atenolol Monotherapy on Serum Lipids, Blood Pressure, Heart Rate, and Weight in Mild to Moderate Hypertension
Houston et al.
ANGIOLOGY 1991;42:681-690.
ABSTRACT  

Management of the patient with intermittent claudication
Cooke and Creager
Vasc Med 1991;2:19-31.
 

Diuretics--Current Issues and Updates
Carasiti
Journal of Pharmacy Practice 1990;3:295-304.
 

Altered State of Consciousness in Adult Ethiopians: Analysis of Aetiological Factors
Endeshaw and Haimanot
The Journal of the Royal Society for the Promotion of Health 1988;108:173-175.
ABSTRACT  

Comparison of Office, Home and 24-Hour Ambulatory Blood Pressures in Borderline and Mild Hypertension
Bialy et al.
ANGIOLOGY 1988;39:752-760.
 

The Effect of {beta}-Blockade on Leg Blood Flow in Hypertensive Patients with Intermittent Claudication
Bostrom et al.
ANGIOLOGY 1986;37:149-153.
ABSTRACT  

The Effects of Health Information in a Worksite Hypertension Screening Program
Zimmerman et al.
Health Educ Behav 1986;13:261-280.
ABSTRACT  

Evaluation of Family Health Education to Build Social Support for Long-Term Control of High Blood Pressure
Morisky et al.
Health Educ Behav 1985;12:35-50.
ABSTRACT  

Let's Get Practical
Taylor
The Counseling Psychologist 1985;13:105-108.
 

The National High Blood Pressure Education Program: A Description of Its Utility as a Generic Program Model
Roccelia and Ward
Health Educ Behav 1984;11:225-242.
ABSTRACT  

Life Stress, Health, and Blood Pressure in Black College Students
Myers et al.
Journal of Black Psychology 1983;9:1-25.
ABSTRACT  

Cardiovascular research: decades of progress, a decade of promise
Levy and Moskowitz
Science 1982;217:121-129.
ABSTRACT  

Treatment Choice in Gastric Carcinoma: A Decision-Analytic Approach
Doubilet and McNeil
Med Decis Making 1982;2:261-274.
 

Intermittent Claudication and Hypertension. Ankle Pressure and Walking Distance in Patients with Well-Treated and Non-Treated Hypertension
Janzon et al.
ANGIOLOGY 1981;32:175-179.
 

Genotoxicity of the antihypertensive drugs hydralazine and dihydralazine
Williams et al.
Science 1980;210:329-330.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1979 American Medical Association. All Rights Reserved.