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Prolactin-Secreting Pituitary AdenomasIII. Frequency and Diagnosis in Amenorrhea-Galactorrhea
William R. Keye, Jr, MD;
R. Jeffrey Chang, MD;
Charles B. Wilson, MD;
Robert B. Jaffe, MD
JAMA. 1980;244(12):1329-1332.
Abstract
Hypocycloidal tomograms of the sella turcica and serum prolactin concentrations were obtained in 146 women with amenorrhea, galactorrhea, or both to diagnose prolactin-secreting pituitary adenomas. Findings suggesting an adenoma, ie, abnormal tomogram and elevated serum prolactin concentration, were found in 24.6% (16/65) of previously unscreened patients and 59.2% (48/81) of prescreened patients. The combination of an abnormal tomogram and elevated prolactin level was relatively specific for an adenoma, as 91% (42/46) of women with these findings who underwent surgery had histologically confirmed tumors. Tumors occurred in women from 15 to 45 years of age, with amenorrhea or galactorrhea ranging from less than six months to more than 20 years in duration. Some women in this series also had obesity, rapid weight loss, polycystic ovarian syndrome, amenorrhea following discontinuance of oral contraceptive use, or emotional stress.
(JAMA 244:1329-1332, 1980)
Author Affiliations
From the Reproductive Endocrinology Center, Department of Obstetrics, Gynecology, and Reproductive Sciences (Drs Keye, Chang, and Jaffe), and the Department of Neurological Surgery (Dr Wilson), University of California, San Francisco. Dr Keye is now with the Department of Obstetrics and Gynecology, University of Utah, Salt Lake City. Dr Chang is now with the Department of Obstetrics and Gynecology, University of California, Los Angeles.
Footnotes
Reprint requests to Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94143 (Dr Jaffe).
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