Hyperaldosteronism, hyperparathyroidism, medullary sponge kidneys, and hypertension
D. E. Hellman, M. Kartchner, N. Komar, D. Mayes and M. Pitt
Hyperparathyroidism and hyperaldosteronism coexisted in association with
medullary sponge kidneys in a 27-year-old woman with severe hypertension. A
modest fall in systolic and diastolic pressure followed removal of a
parathyroid adenoma. Blood pressure was controlled with spironolactone
therapy and restored to normal after removal of an aldosterone-secreting
adrenal tumor. Elevated levels of aldosterone may have been responsible for
the severe hypertension, while hypercalcemia may have had a synergistic
effect on the arteriolar response to circulating vasoactive peptides.
