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Dorothea E. Hellman, MD; Mark Kartchner, MD; Norman Komar, MD; Darrell Mayes, PhD; Michael Pitt, MD

JAMA. 1980;244(12):1351-1353.

Abstract
Hyperparathyroidism and hyperaldosteronism coexisted in association with medullary sponge kidneys in a 27-year-old woman with severe hypertension. A modest fall in systolic and diastolic pressure followed removal of a parathyroid adenoma. Blood pressure was controlled with spironolactone therapy and restored to normal after removal of an aldosterone-secreting adrenal tumor. Elevated levels of aldosterone may have been responsible for the severe hypertension, while hypercalcemia may have had a synergistic effect on the arteriolar response to circulating vasoactive peptides.

(JAMA 244:1351-1353, 1980)

Author Affiliations
From the Tucson Medical Center, Tucson, Ariz (Drs Hellman, Kartchner, and Komar), the Department of Radiology, University of Arizona Health Sciences Center, Tucson (Drs Hellman and Pitt), and the Endocrine Science Laboratory, Tarzana, Calif (Dr Mayes).

Footnotes
Reprint requests to Pima Professional Plaza, Suite 1, 5700 E Pima, Tucson, AZ 85712 (Dr Hellman).

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