This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

The Basis for Prophylaxis in Selected Operations

Hiram C. Polk, Jr, MD; Laura Trachtenberg, MA; Michael P. Finn, MD

JAMA. 1980;244(12):1353-1354.

Abstract
Perioperative antibiotic administration to produce systemic effects reduces the frequency of operative wound infection in selected procedures. Controlled clinical trials now indicate that cephalothin sodium may not be effective in this role, whereas cephaloridine and cefazolin sodium have been beneficial. Review of estimates of incisional antibiotic concentrations taken during prospective patient studies display patterns compatible with these data. Each drug reaches acceptable incisional concentrations, which are relatively well maintained for cephaloridine and cefazolin; cephalothin disappears from human incisions so rapidly as to provide little wound protection in operations lasting more than one hour.

(JAMA 244:1353-1354, 1980)

Author Affiliations
From the Department of Surgery and the Price Institute of Surgical Research, University of Louisville School of Medicine, Health Sciences Center, Louisville.

Footnotes
Reprint requests to Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292 (Dr Polk).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Ensuring Appropriate Timing of Antimicrobial Prophylaxis
Rosenberg et al.
JBJS 2008;90:226-232.
ABSTRACT | FULL TEXT  

Clinical and economic outcomes of pharmacist-managed antimicrobial prophylaxis in surgical patients
Bond and Raehl
Am J Health Syst Pharm 2007;64:1935-1942.
ABSTRACT | FULL TEXT  

Renewal of Surgical Quality and Safety Initiatives: A Multispecialty Challenge
Polk
Mayo Clin Proc. 2006;81:345-352.
ABSTRACT | FULL TEXT  

Exploring obstacles to proper timing of prophylactic antibiotics for surgical site infections
Tan et al.
Qual Saf Health Care 2006;15:32-38.
ABSTRACT | FULL TEXT  

Use of Antimicrobial Prophylaxis for Major Surgery: Baseline Results From the National Surgical Infection Prevention Project
Bratzler et al.
Arch Surg 2005;140:174-182.
ABSTRACT | FULL TEXT  

Does Intraoperative Blood Loss Affect Antibiotic Serum and Tissue Concentrations?
Swoboda et al.
Arch Surg 1996;131:1165-1172.
ABSTRACT  

Interferon Gamma and Tumor Necrosis Factor Alpha: Use in Gram-negative Infection After Shock
Malangoni et al.
Arch Surg 1990;125:444-446.
ABSTRACT  

Intraoperative Serum and Tissue Activity of Cefazolin and Cefoxitin
DiPiro et al.
Arch Surg 1985;120:829-832.
ABSTRACT  

A Remotely Programmable Insulin Delivery System: Successful Short-term Implantation in Man
Schade et al.
JAMA 1982;247:1848-1853.
ABSTRACT