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Samuel Shapiro, MB, FRCP(E); Dennis Slone, MD; David W. Kaufman, MS; Lynn Rosenberg, ScD; Olli S. Miettinen, MD; Paul D. Stolley, MD; Robert C. Knapp, MD; Thomas Leavitt, Jr, MD; Watson G. Watring, MD; Neil B. Rosenshein, MD; David Schottenfeld, MD

JAMA. 1980;244(15):1685-1687.

Abstract
We conducted a case-control study to determine whether the use of thyroid supplements increases the risk of breast cancer. We compared 659 women with breast cancer and 1,719 control subjects. The rates of use of thyroid supplements were 9.1% and 8.7%, respectively (age-standardized rate ratio, 1.0; 95% confidence interval, 0.7 to 1.3). There was no evidence of an association when women known to be at increased risk for breast cancer (eg, nulliparae) were examined, even when thyroid supplements were taken for more than 15 years. Overall, there were no grounds to suggest that the long-term use of thyroid supplements increases the risk of breast cancer.

(JAMA 244:1685-1687, 1980)

Author Affiliations
From the Drug Epidemiology Unit, Boston University Medical Center (Drs Shapiro, Slone, and Rosenberg and Mr Kaufman); the Department of Epidemiology, Harvard School of Public Health, Boston (Dr Miettinen); the Department of Research Medicine, University of Pennsylvania School of Medicine, Philadelphia (Dr Stolley); the Department of Gynecology, Boston Hospital for Women (Drs Knapp and Leavitt); the Division of Gynecologic Oncology, New England Medical Center Hospital, Boston (Dr Watring); the Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Boston (Dr Rosenshein); and the Epidemiology and Preventative Medical Service, Memorial Sloan-Kettering Cancer Center, New York (Dr Schottenfeld).

Footnotes
Reprint requests to 777 Concord Ave, Cambridge, MA 02138 (Dr Shapiro).

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