 |
 |

Use of Thyroid Supplements in Relation to the Risk of Breast Cancer
Samuel Shapiro, MB, FRCP(E);
Dennis Slone, MD;
David W. Kaufman, MS;
Lynn Rosenberg, ScD;
Olli S. Miettinen, MD;
Paul D. Stolley, MD;
Robert C. Knapp, MD;
Thomas Leavitt, Jr, MD;
Watson G. Watring, MD;
Neil B. Rosenshein, MD;
David Schottenfeld, MD
JAMA. 1980;244(15):1685-1687.
Abstract
We conducted a case-control study to determine whether the use of thyroid supplements increases the risk of breast cancer. We compared 659 women with breast cancer and 1,719 control subjects. The rates of use of thyroid supplements were 9.1% and 8.7%, respectively (age-standardized rate ratio, 1.0; 95% confidence interval, 0.7 to 1.3). There was no evidence of an association when women known to be at increased risk for breast cancer (eg, nulliparae) were examined, even when thyroid supplements were taken for more than 15 years. Overall, there were no grounds to suggest that the long-term use of thyroid supplements increases the risk of breast cancer.
(JAMA 244:1685-1687, 1980)
Author Affiliations
From the Drug Epidemiology Unit, Boston University Medical Center (Drs Shapiro, Slone, and Rosenberg and Mr Kaufman); the Department of Epidemiology, Harvard School of Public Health, Boston (Dr Miettinen); the Department of Research Medicine, University of Pennsylvania School of Medicine, Philadelphia (Dr Stolley); the Department of Gynecology, Boston Hospital for Women (Drs Knapp and Leavitt); the Division of Gynecologic Oncology, New England Medical Center Hospital, Boston (Dr Watring); the Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Boston (Dr Rosenshein); and the Epidemiology and Preventative Medical Service, Memorial Sloan-Kettering Cancer Center, New York (Dr Schottenfeld).
Footnotes
Reprint requests to 777 Concord Ave, Cambridge, MA 02138 (Dr Shapiro).
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Do Thyroid Disorders Increase the Risk of Breast Cancer?
Simon et al.
Cancer Epidemiol. Biomarkers Prev. 2002;11:1574-1578.
ABSTRACT
| FULL TEXT
The Aging Thyroid: The Use of Thyroid Hormone in Older Persons
Sawin et al.
JAMA 1989;261:2653-2655.
ABSTRACT
Oral Thyroxine: Variation in Biologic Action and Tablet Content
SAWIN et al.
ANN INTERN MED 1984;100:641-645.
ABSTRACT
Breast Cancer in Hypothyroid Women Using Thyroid Supplements
Hoffman et al.
JAMA 1984;251:616-619.
ABSTRACT
|