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HLA Typing Helpful After Rape

Marilyn S. Pollack, PhD; Irwin A. Schafer, MD; Donald Barford, MD; Bo Dupont, MD, DSc

JAMA. 1980;244(17):1954-1956.

Abstract
The HLA antigen system is extremely polymorphic, and HLA typing is now widely used for both the exclusion and the positive assignment of paternity. We have also used HLA typing for identification of paternity of fetal cells in a pregnancy detected a few weeks after the rape of a woman. The HLA typing indicated that the father of the fetus was the woman's husband, with a probability of 25:1 (96%), before the time the rapist could also be tested. Subsequently, the accused rapist was excluded as a potential father because he lacked all of the paternal antigens detected in the fetus. This prediction was confirmed after delivery.

(JAMA 244:1954-1956, 1980)

Author Affiliations
From the Tissue Typing Laboratory, Sloan-Kettering Institute for Cancer Research, New York (Drs Pollack and Dupont); and the Genetics Program, Department of Pediatrics and Obstetrics, Case Western Reserve University and Cleveland Metropolitan General Hospital, Cleveland (Drs Schafer and Barford).

Footnotes
Reprint requests to Tissue Typing Laboratory, Sloan-Kettering Institute for Cancer Research, 1275 York Ave, New York, NY 10021 (Dr Pollack).

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