Familial Schmidt's syndrome
P. B. Anderson, S. H. Fein and W. G. Frey 3rd
Among the 17 offspring of a common father, overt adrenal and thyroid
insufficiency developed in three brothers. In eight of the 12 siblings then
examined, and also in one of the two mothers of this kindred, endocrine
abnormalities were documented. Early compensated adrenal and thyroid
hypofunction with organ-specific antibodies were found in asymptomatic
relatives. Pernicious anemia, vitiligo, and alopecia were also seen. Age of
clinical onset varied from 18 to 38 years. Familial investigations may
identify asymptomatic persons at risk for the development of serious
endocrine deficiencies.
