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Vaginal Absorption of Povidone-Iodine
Helmuth Vorherr, MD;
Ute F. Vorherr, MT;
Pushpa Mehta, MD;
John A. Ulrich, PhD;
Robert H. Messer, MD
JAMA. 1980;244(23):2628-2629.
Abstract
In 12 nonpregnant women, total iodine, protein-bound iodine, inorganic iodine, and thyroxine values were measured in serum before and 15, 30, 45, or 60 minutes after a two-minute vaginal disinfection with povidone-iodine (Betadine). Only 15 minutes after application, serum iodine levels were raised and remained significantly elevated 30, 45, and 60 minutes after disinfection. Serum concentrations of total iodine and inorganic iodine were increased up to fivefold to 15-fold, respectively; during the relative short period of observation, thyroxine levels were not altered. An overload of iodine can suppress thyroid hormonogenesis, and the fetal and neonatal thyroid glands are especially sensitive. In pregnant women, vaginitis should not be treated with povidone-iodine because of the possible development of iodine-induced goiter and hypothyroidism in the fetus and newborn. The risk is especially high when povidone-iodine is used repeatedly.
(JAMA 1980;244:2628-2629)
Author Affiliations
From the Departments of Obstetrics-Gynecology (Drs Vorherr, Mehta, and Messer and Ms Vorherr), Pharmacology (Dr Vorherr), and Pathology (Dr Ulrich), University of New Mexico School of Medicine, Albuquerque.
Footnotes
Reprint requests to Department of Obstetrics-Gynecology, University of New Mexico School of Medicine, 915 Stanford Dr NE, Albuquerque, NM 87131 (Dr Vorherr).
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