Single-dose amoxicillin therapy for urinary tract infection. Multicenter trial using antibody-coated bacteria localization technique
R. H. Rubin, L. S. Fang, S. R. Jones, R. S. Munford, J. M. Slepack, P. A. Varga, L. Onheiber, C. L. Hall and N. E. Tolkoff-Rubin
Urine specimens from 134 women with acute, uncomplicated urinary tract
infection at three medical centers were examined by the antibody-coated
bacteria (ACB) assay. Patients with negative assays (suggesting bladder
infection alone) were randomized to receive either a single 3-g oral dose
of amoxicillin trihydrate or conventional ten-day courses of
sulfa-methoxazole-trimethoprim or oral ampicillin sodium. Comparable
results were obtained with the three regimens for ACG-negative infection:
90% eradication of the original organism with single-dose amoxicillin, 100%
with sulfamethoxazole-trimethoprim, and 96% with ampicillin. The overall
incidence of ACB positivity was 32.1%, ranging from 8% to 63% at the three
institutions. This difference seemed to be related to the ease of access to
medical care: women with easy access having low rates of ACB positivity and
those with poor access having high rates.
