 |
|
Single-Dose Amoxicillin Therapy for Urinary Tract InfectionMulticenter Trial Using Antibody-Coated Bacteria Localization Technique
Robert H. Rubin, MD;
Leslie S. T. Fang, MD, PhD;
Stephen R. Jones, MD;
Robert S. Munford, MD;
J. M. Slepack, MD;
Patricia A. Varga, MA;
Linda Onheiber, PA;
Catherine L. Hall, MS;
Nina E. Tolkoff-Rubin, MD
JAMA. 1980;244(6):561-564.
Abstract
Urine specimens from 134 women with acute, uncomplicated urinary tract infection at three medical centers were examined by the antibody-coated bacteria (ACB) assay. Patients with negative assays (suggesting bladder infection alone) were randomized to receive either a single 3-g oral dose of amoxicillin trihydrate or conventional ten-day courses of sulfamethoxazole-trimethoprim or oral ampicillin sodium. Comparable results were obtained with the three regimens for ACB-negative infection: 90% eradication of the original organism with single-dose amoxicillin, 100% with sulfamethoxazole-trimethoprim, and 96% with ampicillin. The overall incidence of ACB positivity was 32.1%, ranging from 8% to 63% at the three institutions. This difference seemed to be related to the ease of access to medical care: women with easy access having low rates of ACB positivity and those with poor access having high rates.
(JAMA 244:561-564, 1980)
Author Affiliations
From the Medical Services, Massachusetts General Hospital, Boston (Drs Rubin, Fang, and Tolkoff-Rubin and Ms Varga); the Medical Services, Parkland Memorial Hospital, Dallas (Dr Munford and Ms Hall); the Kaiser-Permanente Health Program of Oregon, Portland (Dr Slepack and Ms Onheiber); the Department of Medicine, Harvard Medical School, Cambridge, Mass (Drs Rubin, Fang, and Tolkoff-Rubin); the Department of Medicine, University of Texas Southwestern Medical School, Dallas (Dr Munford); and the Department of Medicine, University of Oregon Health Sciences Center, Portland (Drs Jones and Slepack).
Footnotes
Presented in part at the 18th Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlanta, Oct 2, 1978.
Reprint requests to Infectious Disease Unit, Massachusetts General Hospital, Boston, MA 02114 (Dr Rubin).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
A Meta-analysis of Randomized, Controlled Trials Comparing Short- and Long-Course Antibiotic Therapy for Urinary Tract Infections in Children
Keren and Chan
Pediatrics 2002;109:e70-70.
ABSTRACT
| FULL TEXT
Increasing Antimicrobial Resistance and the Management of Uncomplicated Community-Acquired Urinary Tract Infections
Gupta et al.
ANN INTERN MED 2001;135:41-50.
ABSTRACT
| FULL TEXT
Is Treatment of Acute Otitis Media With Once-a-Day Amoxicillin Feasible?: Results of a Pilot Study
Murph et al.
CLIN PEDIATR 1993;32:528-534.
ABSTRACT
Urinary Tract Infections in Women: Diagnosis and Treatment
Johnson and Stamm
ANN INTERN MED 1989;111:906-917.
ABSTRACT
Trimethoprim-Sulfamethoxazole for Acute Dysuria in Women: A Single-Dose or 10-Day Course: A Double-Blind, Randomized Trial
FIHN et al.
ANN INTERN MED 1988;108:350-357.
ABSTRACT
Acute Renal Infection in Women: Treatment with Trimethoprim-Sulfamethoxazole or Ampicillin for Two or Six Weeks: A Randomized Trial
STAMM et al.
ANN INTERN MED 1987;106:341-345.
ABSTRACT
Therapy vs No Therapy for Bacteriuria in Elderly Ambulatory Nonhospitalized Women
Boscia et al.
JAMA 1987;257:1067-1071.
ABSTRACT
Diagnostic Decision: Urinalysis and Urine Culture in Women with Dysuria
KOMAROFF
ANN INTERN MED 1986;104:212-218.
ABSTRACT
Single-Dose Antibiotic Treatment for Uncomplicated Urinary Tract Infections: Less for Less?
Philbrick and Bracikowski
Arch Intern Med 1985;145:1672-1678.
ABSTRACT
Management of Recurrent Urinary Tract Infections with Patient-Administered Single-Dose Therapy
WONG et al.
ANN INTERN MED 1985;102:302-307.
ABSTRACT
Management of Acute Dysuria: A Decision-Analysis Model of Alternative Strategies
CARLSON and MULLEY
ANN INTERN MED 1985;102:244-249.
ABSTRACT
Single-Dose Therapy for Cystitis in Women: A Comparison of Trimethoprim-Sulfamethoxazole, Amoxicillin, and Cyclacillin
Hooton et al.
JAMA 1985;253:387-390.
ABSTRACT
Therapy for Acute Cystitis in Adult Women: Randomized Comparison of Single-Dose Sulfisoxazole vs Trimethoprim-Sulfamethoxazole
Buckwold et al.
JAMA 1982;247:1839-1842.
ABSTRACT
Is Antimicrobial Prophylaxis of Urinary Tract Infections Cost Effective?
STAMM et al.
ANN INTERN MED 1981;94:251-255.
ABSTRACT
Urinary Infection Prophylaxis in Women
RONALD and HARDING
ANN INTERN MED 1981;94:268-270.
ABSTRACT
|
