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Peripheral Source of MB Band of Creatine Kinase in Alcoholic RhabdomyolysisNonspecificity of MB Isoenzyme for Myocardial Injury in Undiluted Serum Samples
Arthur J. Siegel, MD;
David M. Dawson, MD
JAMA. 1980;244(6):580-582.
Abstract
The MB isoenzyme of creatine kinase (CK MB) was strongly positive in the serum of a patient with alcoholic rhabdomyolysis, and it remained detectable by a standard qualitative assay over a two-year period without clinical or laboratory evidence of myocardial disease. MB isoenzyme was also demonstrated in a homogenate of skeletal muscle. Isoenzyme determinations in serum and tissue were repeated after dilution of total CK activity to the range optimal for the assay (300 IU/L). Such dilution before isoenzyme separation rendered these samples negative for CK MB. The MB isoenzyme may be detectable in serum from peripheral sources in the presence of high total CK concentrations.
(JAMA 244:580-582, 1980)
Author Affiliations
From the Division of General Medicine (Dr Siegel) and Neurology (Dr Dawson), Department of Medicine, Peter Bent Brigham Hospital, Boston.
Footnotes
Reprint requests to Division of General Medicine, Peter Bent Brigham Hospital, 721 Huntington Ave, Boston, MA 02115 (Dr Siegel).
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