This Article  • References  • Full text PDF  • Correction  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (153)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Mortimer M. Bortin, MD; Robert P. Gale, MD, PhD; Alfred A. Rimm, PhD

JAMA. 1981;245(11):1132-1139.

Abstract
Comprehensive data were reported to the International Bone Marrow Transplant Registry by 24 worldwide teams regarding 144 patients with severe aplastic anemia who were treated with HLA-identical, allogeneic bone marrow transplantation between 1975 and 1978. One hundred fourteen patients received one transplant and 30 received two. Sustained engraftment of donor marrow occurred on the first transplant attempt in 76% of the patients whose engraftment status could be evaluated. Moderate, severe, or lethal graft-vs-host disease (GVHD) occurred in 52% of the engrafted patients. The one-year survival rate for all patients was 44% (64/144). Among the one-year survivors, the primary disease was apparently cured in 90% and improved in 10%. Thus far, four patients died one to five years after transplant. Of the 60 patients currently alive, ten have chronic GVHD and the remainder are in good health. Multivariate analyses of the data disclosed a number of pretransplant factors associated with engraftment, GVHD, and one-year survival. The most important finding was that the use of male donors was preferable to female donors because of a higher rate of engraftment, less severe GVHD, and a higher one-year survival rate.

(JAMA 1981;245:1132-1139)

Footnotes
Eleventh report from the International Bone Marrow Transplant Registry, Milwaukee.

Reprint requests to International Bone Marrow Transplant Registry, 950 N 12th St, Milwaukee, WI 53233 (Dr Bortin).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Risk factors for acute graft-versus-host disease in patients undergoing transplantation with CD34+ selected blood cells from HLA-identical siblings
Urbano-Ispizua et al.
Blood 2002;100:724-727.
ABSTRACT | FULL TEXT  

Bone Marrow Transplantation for Severe Aplastic Anemia: Has Outcome Improved?
Passweg et al.
Blood 1997;90:858-864.
ABSTRACT | FULL TEXT  

Outcome After Allogeneic Bone Marrow Transplant for Leukemia in Older Adults
Ringden et al.
JAMA 1993;270:57-60.
ABSTRACT  

The Eye in Bone Marrow Transplantation: III. Conjunctival Graft-vs-Host Disease
Jabs et al.
Arch Ophthalmol 1989;107:1343-1348.
ABSTRACT  

Transplantation Immunology
Kirkpatrick
JAMA 1987;258:2993-3000.
ABSTRACT  

Immediate Medical Consequences of Nuclear Accidents: Lessons From Chernobyl
Gale
JAMA 1987;258:625-628.
ABSTRACT  

Marrow Transplantation for Severe Aplastic Anemia: Long-Term Outcome in Fifty "Untransfused" Patients
ANASETTI et al.
ANN INTERN MED 1986;104:461-466.
ABSTRACT  

Interstitial Pneumonitis After Bone Marrow Transplantation: Assessment of Risk Factors
WEINER et al.
ANN INTERN MED 1986;104:168-175.
ABSTRACT  

Graft-v-Host Disease
James and Odom
Arch Dermatol 1983;119:683-689.
ABSTRACT  

Bone Marrow Transplantation for Acute Myelogenous Leukemia: Factors Associated With Early Mortality
Bortin et al.
JAMA 1983;249:1166-1175.
ABSTRACT  

Transplantation Immunology: Clinical Aspects
Kirkpatrick and Leech
JAMA 1982;248:2727-2733.
ABSTRACT  

Aplastic Anemia: Biology and Treatment
GALE et al.
ANN INTERN MED 1981;95:477-494.
ABSTRACT