Vitamin B12 deficiency and early rise in mean corpuscular volume

doi:10.1001/jama.245.11.1144

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Vol. 245 No. 11, March 20, 1981

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Vitamin B12 deficiency and early rise in mean corpuscular volume

C. A. Hall

An increase in the mean corpuscular volume (MCV), while not diagnostic of vitamin B12 or folate deficiency, is a valuable, readily available screening test. I discuss six instances where an increased MCV was recorded months prior to diagnosis and could, if noted, have led to an earlier diagnosis.

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