This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Roger R. Williams, MD; Paul D. Sorlie, MS; Manning Feinleib, MD, DrPH; Patricia M. McNamara, MS; William B. Kannel, MD; Thomas R. Dawber, MD

JAMA. 1981;245(3):247-252.

Abstract
In 5,209 subjects studied for 24 years in Framingham, Mass, 691 cases of cancer were documented, with histological confirmation for 94%. Predetermined personal characteristics were tested for associations with subsequent occurrence of cancer at specific sites using multiple logistic regression. Significant associations of various cancer sites with cigarette smoking, alcohol use, education, height, weight, and parity agreed with other studies. Serum cholesterol level was inversely associated with incidence of colon cancer and with other sites only in men; these inverse associations were statistically significant after adjustment for age, alcohol consumption, cigarette smoking, education, systolic blood pressure, and relative weight. Associations may reflect effects of competing lethal diseases, underlying pathophysiological mechanisms that promote or inhibit development of cancer in men, biologic or social response to early and undiagnosed states of cancer.

(JAMA 1981;245:247-252)

Author Affiliations
From the Epidemiology Branch (Drs Williams and Feinleib) and Biometrics Research Branch (Mr Sorlie), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md; the National Heart, Lung, and Blood Institute Framingham (Mass) Study (Ms McNamara and Dr Kannel); and the Boston University Medical Center (Dr Dawber). Dr Williams is currently with the Department of Internal Medicine, University of Utah Medical Center, Salt Lake City.

Footnotes
Reprint requests to National Institutes of Health, Federal Building, Room 2C16B, Bethesda, MD 20205 (Mr Sorlie).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Prediagnostic Total and High-Density Lipoprotein Cholesterol and Risk of Cancer
Ahn et al.
Cancer Epidemiol. Biomarkers Prev. 2009;18:2814-2821.
ABSTRACT | FULL TEXT  

Time-dependent association of total serum cholesterol and cancer incidence in a cohort of 172 210 men and women: a prospective 19-year follow-up study
Strasak et al.
Ann Oncol 2009;20:1113-1120.
ABSTRACT | FULL TEXT  

Diabetes, metabolic syndrome, and breast cancer: a review of the current evidence
Xue and Michels
Am. J. Clin. Nutr. 2007;86:823S-835S.
ABSTRACT | FULL TEXT  

Metabolic Abnormalities and Risk for Colorectal Cancer in the Physicians' Health Study
Sturmer et al.
Cancer Epidemiol. Biomarkers Prev. 2006;15:2391-2397.
ABSTRACT | FULL TEXT  

Serum Lipids, Lipid-Lowering Drugs, and the Risk of Breast Cancer
Eliassen et al.
Arch Intern Med 2005;165:2264-2271.
ABSTRACT | FULL TEXT  

The Munster Heart Study (PROCAM) : Total Mortality in Middle-Aged Men Is Increased at Low Total and LDL Cholesterol Concentrations in Smokers but Not in Nonsmokers
Cullen et al.
Circulation 1997;96:2128-2136.
ABSTRACT | FULL TEXT  

Serum Total Cholesterol and Mortality: Confounding Factors and Risk Modification in Japanese-American Men
Iribarren et al.
JAMA 1995;273:1926-1932.
ABSTRACT  

Plasma Cholesterol Concentration and Mortality: The Whitehall Study
Smith et al.
JAMA 1992;267:70-76.
ABSTRACT  

Declining Serum Cholesterol Levels Prior to Diagnosis of Colon Cancer: A Time-Trend, Case-Control Study
Winawer et al.
JAMA 1990;263:2083-2085.
ABSTRACT  

Cholesterol and Mortality: 30 Years of Follow-up From the Framingham Study
Anderson et al.
JAMA 1987;257:2176-2180.
ABSTRACT  

Cholesterol Reduction and Life Expectancy: A Model Incorporating Multiple Risk Factors
TAYLOR et al.
ANN INTERN MED 1987;106:605-614.
ABSTRACT  

Serum Cholesterol Levels and Cancer Mortality in 361662 Men Screened for the Multiple Risk Factor Intervention Trial
Sherwin et al.
JAMA 1987;257:943-948.
ABSTRACT  

Dietary and Pharmacologic Therapy for the Lipid Risk Factors
Council on Scientific Affairs
JAMA 1983;250:1873-1879.
ABSTRACT  

Circulating Cholesterol Level and Risk of Death From Cancer in Men Aged 40 to 69 Years: Experience of an International Collaborative Group
International Collaborative Group
JAMA 1982;248:2853-2859.
ABSTRACT  

Cholesterol and Disease--What Are the Facts?
Levy
JAMA 1982;248:2888-2890.
ABSTRACT  

Cholesterol, Coronary Disease, and Cancer
Jones
JAMA 1981;245:2060-2060.
ABSTRACT