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Possible Relationship to Long-term Oral Contraceptive Ingestion

Paul S. Monroe, MD; Robert H. Riddell, MD; Mark Siegler, MD; Alfred L. Baker, MD

JAMA. 1981;246(1):64-65.

Abstract
A 32-year-old woman with an eight-year history of oral contraceptive use was found at laparotomy to have a hepatic angiosarcoma. The prolonged exposure to contraceptive hormones may have been a factor in the development of this rare tumor. The estrogens and progestins contained in oral contraceptives are biochemically similar to the anabolic-androgenic steroids that have recently been reported to cause hepatic angiosarcoma.

(JAMA 1981;246:64-65)

Author Affiliations
From the Liver Study Unit (Drs Monroe and Baker) and the Section of General Internal Medicine (Dr Siegler), Department of Medicine and the Department of Pathology (Dr Riddell), University of Chicago Hospitals and Clinics.

Footnotes
Reprint requests to Department of Medicine, University of Chicago, Box 400, 950 E 59th St, Chicago, IL 60637 (Dr Baker).

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