Single high-dose pyridoxine treatment for isoniazid overdose
S. Wason, P. G. Lacouture and F. H. Lovejoy Jr
We treated five isoniazid-overdosed patients each with a single dose of
pyridoxine hydrochloride equivalent to the gram amount of isoniazid
ingested and compared their outcome with that of 41 patients from the
literature who received little or no pyridoxine. Recurrent seizures
occurred in 60% of patients who had received no pyridoxine vs 0% in our
patients. Metabolic acidosis resolved in our cases but was refractory in
the literature cases. In our cases, coma lightened more rapidly and was of
shorter duration as compared with that in the literature cases (mean, seven
hours vs 24 hours). No adverse effects of pyridoxine were seen in our
patients.
