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Stephen R. Preblud, MD; Harrison C. Stetler, MD; John A. Frank, Jr, MD; Wayne L. Greaves, MD; Alan R. Hinman, MD; Kenneth L. Herrmann, MD

JAMA. 1981;246(13):1413-1417.

Abstract
Ninety-four susceptible women received either Cendehill or HPV-77 rubella vaccine. All gave birth to healthy infants. Seventeen susceptible women received the RA 27/3 vaccine. All their infants were free of abnormalities compatible with congenital rubella, as were 54 born to mothers of unknown immune status at the time of RA 27/3 vaccination and those later found to be immune. An additional susceptible woman received an unknown strain of vaccine; she also had a healthy infant. The risk of severe congenital malformations after rubella vaccination is low. In our 112 cases, the maximum risk was approximately 3%. Concern about the potential adverse effects of rubella vaccine on the fetus should not interfere with vaccination of women of childbearing age. However, since the actual risk may not be zero, women known to be pregnant should not be vaccinated, and conception should be avoided for three months after vaccination.

(JAMA 1981;246:1413-1417)

Author Affiliations
From the Immunization Division, Center for Prevention Services (Drs Preblud, Stetler, Frank, Greaves, and Hinman), and the Perinatal Virology Branch, Virology Division, Center for Infectious Diseases (Dr Herrmann), US Department of Health and Human Services, Public Health Service, Centers for Disease Control, Atlanta. Dr Preblud is now with The Children's Hospital of Philadelphia. Dr Frank is now with Duke University Medical Center, Durham, NC.

Footnotes
Presented in part at the 20th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Sept 23, 1980.

Reprint requests to Centers for Disease Control, 1600 Clifton Rd NE, Atlanta, GA 30333 (Dr Hinman).

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