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Miron Baron, MD; Morton Levitt, PhD; Richard Perlman, PhD

JAMA. 1981;246(13):1418-1421.

Abstract
Platelet monoamine oxidase (MAO) activity is significantly reduced in chronic schizophrenics with family history of schizophrenia. The degree of reduction is related to the extent of genetic load. Schizophrenics with no affected relatives do not differ from control subjects. These findings are consistent with the hypothesis of genetic heterogeneity in schizophrenia. Discrepancies among previously reported data sets can thus be explained by overrepresentation of nongenetic phenocopies with normal MAO levels. The implications for biologic and genetic research in schizophrenia are discussed.

(JAMA 1981;246:1418-1421)

Author Affiliations
From the Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the Department of Medical Genetics, New York State Psychiatric Institute, New York.

Footnotes
Reprint requests to Department of Psychiatry, New York State Psychiatric Institute, 722 W 168th St, New York, NY 10032 (Dr Baron).

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