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In Utero Epstein-Barr Virus (Infectious Mononucleosis) Infection
Gerald N. Goldberg, MD;
Vincent A. Fulginiti, MD;
C. George Ray, MD;
Peggy Ferry, MD;
James F. Jones, MD;
Harold Cross, MD;
Linda Minnich, MS
JAMA. 1981;246(14):1579-1581.
Abstract
A male infant infected in utero with Epstein-Barr virus (EBV) demonstrated a syndrome of multiple congenital anomalies (micrognathia, cryptorchidism, central cataracts), hypotonia, thrombocytopenia, persistent monocytosis, proteinuria, and multiple areas of metaphysitis at birth. Lymphocytes were Epstein-Barr nuclear antigen (EBNA) positive (18%) and persisted in culture for three months. He had antibody to early antigen (anti-EA), IgM-viral capsid (anti-VCA), and EBNA (anti-EBNA) detectable at 22 days of age. All attempts to isolate infectious agents or to serologically identify other infectious causes for his syndrome were negative.
(JAMA 1981;246:1579-1581)
Author Affiliations
From the Departments of Pediatrics (Drs Goldberg, Fulginiti, Ray, Ferry, and Jones), Pathology (Dr Ray and Ms Minnich), Neurology (Dr Ferry), and Surgery (Ophthalmology) (Dr Cross), Arizona Health Sciences Center, Tucson.
Footnotes
Reprint requests to Department of Pediatrics, Arizona Health Sciences Center, 1501 N Campbell Ave, Tucson, AZ 84724 (Dr Fulginiti).
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