In utero Epstein-Barr virus (infectious mononucleosis) infection
G. N. Goldberg, V. A. Fulginiti, C. G. Ray, P. Ferry, J. F. Jones, H. Cross and L. Minnich
A male infant infected in utero with Epstein-Barr virus (EBV) demonstrated
a syndrome of multiple congenital anomalies (micrognathia, cryptorchidism,
central cataracts), hypotonia, thrombocytopenia, persistent monocytosis,
proteinuria, and multiple areas of metaphysitis at birth. Lymphocytes were
Epstein-Barr nuclear antigen (EBNA) positive (18%) and persisted in culture
for three months. He had antibody to early antigen (anti-EA), IgM-viral
capsid (anti-VCA), and EBNA (anti-EBNA) detectable at 22 days of age. All
attempts to isolate infectious agents or to serologically identify other
infectious causes for his syndrome were negative.
