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Ralph A. Kelly, MD; Jeffrey A. Gelfand, MD; Stephanie H. Pincus, MD

JAMA. 1981;246(14):1582-1583.

Abstract
Two cases of cutaneous necrosis occurred that were caused by intravenous administration of porcine heparin for deep venous thrombophlebitis. The lesions grossly resembled those of warfarin sodium-induced skin necrosis. However, histologically, no fibrin thrombi were noted in capillaries and vessels, a characteristic finding in warfarin necrosis. There was no evidence of vasculitis in the lesions. Both patients subsequently received warfarin without complications.

(JAMA 1981;246:1582-1583)

Author Affiliations
From the Departments of Medicine (Drs Kelly and Gelfand) and Dermatology (Dr Pincus), Tufts University School of Medicine and Tufts-New England Medical Center Hospital, Boston.

Footnotes
Reprint requests to Department of Dermatology, Tufts-New England Medical Center Hospital, 171 Harrison Ave, Boston, MA 02111 (Dr Pincus).

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