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Marilyn Galler, MD; Vaughn W. Folkert, MD; Detlef Schlondorff, MD

JAMA. 1981;246(2):154-155.

Abstract
We noted five cases of reversible acute deterioration of renal function in patients with very mild to moderate renal insufficiency who received indomethacin for an acute gouty attack. This decrease in renal function was consistent with a primary decrease in renal blood flow. In addition, hyperkalemia developed in the patients, which we attribute to a decrease in renin and aldosterone secretion, a decrease in distal tubular delivery of sodium, and, more importantly, to a decrease in urine flow. This report is intended to alert physicians to the possible complications of indomethacin therapy in patients with mild renal insufficiency.

(JAMA 1981;246:154-155)

Author Affiliations
From the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY.

Footnotes
Reprint requests to Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461 (Dr Galler).

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