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John Ducas, MD; Hugh G. Robson, MD

JAMA. 1981;246(22):2583-2584.

Abstract
Cerebrospinal fluid and serum penicillin levels were determined in patients with latent syphilis. Mean serum concentration one week after the third weekly dose of 2.4 million units penicillin G benzathine was 0.32 units/mL. Concurrent administration of probenecid orally produced a mean serum penicillin level of 0.41 units/mL. Doubled penicillin doses without and with daily orally administered probenecid resulted in mean serum concentrations of 0.75 and 1.00 units/mL, respectively. Two of six patients in the last group had CSF penicillin concentrations greater than 0.03 units/mL.

(JAMA 1981;246:2583-2584)

Author Affiliations
From the Departments of Medicine (Drs Ducas and Robson) and Microbiology (Dr Robson), Royal Victoria Hospital and McGill University, Montreal.

Footnotes
Presented in part at a meeting of the Canadian Society for Clinical Investigation, Ottawa, Oct 1, 1980.

Reprint requests to Department of Microbiology and Immunology, 3775 University St, Montreal, Quebec, Canada H3A 2B4 (Dr Robson).

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