Dural sinus thrombosis in children with acute lymphoblastic leukemia
P. G. Steinherz, L. P. Miller, F. Ghavimi, J. C. Allen and D. R. Miller
Dural sinus thrombosis developed in two children with acute lymphoblastic
leukemia during induction treatment with vincristine sulfate, prednisone,
and asparaginase. Headache, nausea, emesis, and lethargy were the
presenting signs. The diagnosis was confirmed by arteriography. The cause
is presumed to be secondary to hypercoagulability due to
asparaginase-induced antithrombin III deficiency. The patients received
anticoagulation therapy and recovered completely. Only two of the six
reported patients without heparinization survived.
