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P. Joan Chesney, MD; Jeffrey P. Davis, MD; William K. Purdy, MD; Philip J. Wand; Russell W. Chesney, MD

JAMA. 1981;246(7):741-748.

Abstract
Twenty-two women aged 13 to 44 years (mean, 22 years) with toxic shock syndrome (TSS) were hospitalized in Madison, Wis, between Aug 1, 1977, and Sept 1, 1980. Disease onset occurred during menses in 21 patients; all recovered. Notable sequelae included vocal cord paralysis and impaired finger sensation in two patients and recurrent disease in three. Coagulase-positive staphylococci were grown from the cervix or vagina in 11 of 12 women cultured. Previously undescribed features included vulvar cellulitis, hypocalcemia, hypophosphatemia, hypocholesterolemia, hyponatremia, lymphocytopenia, hypoferrinemia, and late convalescent hair and nail loss. Patients requiring dopamine hydrochloride had worse renal function, longer hospitalizations, and higher total serum bilirubin levels, and clinical onset earlier in menses. Originally reported in children, TSS now appears to be primarily a disease of menstruating women in whom recurrences are possible.

(JAMA 1981;246:741-748)

Author Affiliations
From the Departments of Pediatrics and Preventive Medicine, the University of Wisconsin Center for Health Sciences (Drs P. Joan Chesney and Russell W. Chesney); the Bureau of Prevention, Wisconsin Division of Health (Dr Davis), Madison; Rambling Road Clinic, Kalamazoo, Mich (Dr Purdy); and the Bacteriology Laboratory, Wisconsin State Laboratory of Hygiene (Mr Wand), Madison.

Footnotes
Presented in part before the 20th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Sept 24, 1980.

Reprint requests to Clinical Science Center H4/430, 600 Highland Ave, Madison, WI 53792 (Dr P. Joan Chesney).

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