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Evidence for Tetracycline in Adult Human Bone

Sally A. Oklund, PhD; Donald J. Prolo, MD; Robert V. Gutierrez

JAMA. 1981;246(7):761-763.

Abstract
Tetracycline binds to growing bone and imparts a brilliant and fluorescent yellow to this tissue. The cumulative deposition of tetracycline in cortical bone during many years resulted in levels of 156, 270, and 290 µg/g, respectively, of bone wet weight in three patients who used this antibiotic for acne vulgaris. Although tetracycline in high doses impairs mineralization of growing bone in the fetus and young, its long-term use in therapeutic dosages in the human adult has no known deleterious effect. Yellow bone appears safe for the human carrier and as a transplantable tissue.

(JAMA 1981;246:761-763)

Author Affiliations
From the Neuroskeletal Transplantation Laboratory, Institute for Medical Research, San Jose, Calif.

Footnotes
Reprint requests to Neuroskeletal Transplantation Laboratory, Institute for Medical Research, 751 S Bascom Ave, San Jose, CA 95128 (Dr Prolo).

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