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Raymond A. Sturner, MD; Stephen Denning, MD; Patricia Marchase, MD

JAMA. 1981;246(7):763-765.

Abstract
Acanthosis nigricans has been associated with malignant diseases and endocrinopathy. One of the cases reported herein and a review of 12 others suggest that the onset of acanthosis nigricans may predate a variety of classic autoimmune diseases. The other case being reported now, along with a literature review of 22 cases, suggests that acanthosis nigricans also may be associated with disordered immunoreactivity not fitting any clinically recognizable syndrome.

(JAMA 1981;246:763-765)

Author Affiliations
From the Departments of Pediatrics (Dr Sturner) and Dermatology (Dr Marchase), Duke University Medical Center, Durham, NC; and the Department of Internal Medicine, University of Chicago (Dr Denning).

Footnotes
Reprint requests to PO Box 3890, Duke University Medical Center, Durham, NC 27710 (Dr Sturner).

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ABSTRACT