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Theodore A. Petti, MD; William Law III, MD

JAMA. 1981;246(7):768-769.

Abstract
Two children in whom imipramine hydrochloride therapy was abruptly discontinued experienced nausea, frequent vomiting, headache, lethargy, and irritability. These symptoms were similar to but more intense than those previously reported in children during gradual tapering of imipramine dosages. Physicians who treat children should be aware that symptoms previously thought to be side effects of imipramine may in fact represent noncompliance and resultant withdrawal.

(JAMA 1981;246:768-769)

Author Affiliations
From the Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine.

Footnotes
Reprint requests to Western Psychiatric Institute and Clinic, 3811 O'Hara St, Pittsburgh, PA 15261 (Dr Petti).

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