Pure red cell aplasia associated with sodium valproate therapy
L. G. MacDougall
Pure red cell aplasia developed in a 9-year-old girl receiving sodium
valproate therapy. Infection with measles and chickenpox had occurred two
months previously. Regeneration of bone marrow erythroid precursors was
demonstrated one month after drug withdrawal. Readministration of sodium
valproate resulted in a second episode of red cell aplasia that again
resolved promptly after drug withdrawal. The respective roles of infection
and drugs in the etiology of red cell aplasia are discussed.
