This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Sandra J. Horning, MD; Jedd F. Levine, MD; Richard A. Miller, MD; Saul A. Rosenberg, MD; Thomas C. Merigan, MD

JAMA. 1982;247(12):1718-1722.

Abstract
The clinical and immunologic effects of a biosynthetic human leukocyte interferon, recombinant leukocyte A interferon (IFL-rA), are reported in eight patients with advanced cancer. Single escalating doses from 3x10⁶ units to 198x10⁶ units were given by intramuscular injection in a phase 1 study. Major toxic effects included pyrexia, fatigue, myalgia, and headache. Data on the effects of IFL-rA on lymphocyte subpopulations and peripheral blood mononuclear-cell surface β₂-microglobulin are presented. Four of eight patients had objective tumor regression, indicating that further investigation of this biologically active material is warranted.

(JAMA 1982;247:1718-1722)

Author Affiliations
From the Department of Medicine, Stanford University School of Medicine, Stanford, Calif.

Footnotes
Reprint requests to Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA 94305 (Dr Merigan).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Understanding Cytokines Part I: Physiology and Mechanism of Action
Corwin
Biol Res Nurs 2000;2:30-40.
ABSTRACT  

High-Dose Recombinant Interleukin 2 in the Treatment of Patients With Disseminated Cancer: Responses, Treatment-Related Morbidity, and Histologic Findings
Lotze et al.
JAMA 1986;256:3117-3124.
ABSTRACT  

Recombinant Leukocyte A Interferon in Advanced Breast Cancer: Results of a Phase II Efficacy Trial
SHERWIN et al.
ANN INTERN MED 1983;98:598-602.
ABSTRACT  

A Multiple-Dose Phase I Trial of Recombinant Leukocyte A Interferon in Cancer Patients
Sherwin et al.
JAMA 1982;248:2461-2466.
ABSTRACT  

Interferon--The First Quarter Century
Merigan
JAMA 1982;248:2513-2516.
ABSTRACT