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Results of Initial Clinical Studies of Preexposure Vaccination

Byron S. Berlin, MD; John R. Mitchell, DVM; George H. Burgoyne, PhD; Dunlap Oleson, MD; William E. Brown, MD; Claude Goswick, MD; Norman B. McCullough, MD, PhD

JAMA. 1982;247(12):1726-1728.

Abstract
To meet the need for a safe, efficacious, and low-cost rabies vaccination program, the Michigan Department of Public Health developed a new rabies vaccine: rhesus diploid rabies vaccine, adsorbed (RDRV). Initial clinical studies were conducted in 534 volunteers using preexposure protocols consisting of two injections of RDRV given 1, 2, or 4 weeks apart. This new rabies vaccine induced an excellent rabies virus antibody response two to three weeks after vaccination: antibody levels were superior to those reported after duck embryo rabies vaccine and were similar to those reported with human diploid rabies vaccine. In addition, vaccination with RDRV was associated with an acceptable level of local and constitutional symptoms.

(JAMA 1982;247:1726-1728)

Author Affiliations
From the Bureau of Disease Control and Laboratory Services, Michigan Department of Public Health, Lansing (Drs Berlin, Burgoyne, and Mitchell); the Drake Student Health Center, Auburn University, Auburn, Ala (Dr Oleson); the University Health Service, Ohio State University, Columbus (Dr Brown); the A. P. Beutel Health Center, Texas A&M University, College Station (Dr Goswick); and the Department of Medicine, Microbiology, and Public Health, Michigan State University, East Lansing, Mich (Dr McCullough).

Footnotes
Reprint requests to Bureau of Disease Control and Laboratory Services, Michigan Department of Public Health, 3500 N Logan St, Lansing, MI 48909 (Dr Berlin).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Rhesus Diploid Rabies Vaccine (Adsorbed), A New Rabies Vaccine: II. Results of Clinical Studies Simulating Prophylactic Therapy for Rabies Exposure
Berlin et al.
JAMA 1983;249:2663-2665.
ABSTRACT