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Thomas L. Lowe, MD; Donald J. Cohen, MD; Jill Detlor, RN; Martin W. Kremenitzer, MD; Bennett A. Shaywitz, MD

JAMA. 1982;247(12):1729-1731.

Abstract
Following treatment with stimulant medications for symptoms of attention deficit disorder, Gilles de la Tourette's syndrome occurred in 15 patients. Early signs of Tourette's syndrome may be difficult to distinguish from hyperactive and attention disordered symptoms, leading the clinician to consider treatment with stimulants. In these Tourette's-susceptible patients, stimulants may exacerbate severe motor and phonic tics, requiring discontinuation of administration of stimulants and institution of haloperidol therapy for tic control. Clinical evaluation for tics and Tourette's syndrome in children and their families should precede and dictate use of stimulant medications in children.

(JAMA 1982;247:1729-1731)

Author Affiliations
From the Child Study Center and Department of Psychiatry (Drs Lowe and Cohen and Ms Detlor), the Department of Pediatrics (Drs Lowe, Cohen, and Shaywitz), and the Department of Neurology (Drs Kremenitzer and Shaywitz), Yale University School of Medicine, New Haven, Conn. Dr Lowe is presently with the Department of Psychiatry, University of South Florida College of Medicine, Tampa.

Footnotes
Reprint requests to Child Study Center, 333 Cedar St, New Haven, CT 06510 (Dr Cohen).

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