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Neurological Manifestations of AngioedemaReport of Two Cases and Review of the Literature
CDR Theodore R. Sunder, MC;
CDR Marion J. Balsam, MC;
LT Michael I. Vengrow, MC
JAMA. 1982;247(14):2005-2007.
Abstract
Two children had recurrent neurological symptoms associated with angioedema. Extensive clinical and laboratory investigations failed to reveal a separate cause for the neurological changes. Only 19 prior cases of this association have been reported. Seizures and headaches are the most common symptoms, but a wide variety of focal and generalized deficits may occur. The release of vasoactive substances such as histamine, serotonin, and prostaglandins, which are also putative neurotransmitters, is postulated to be the cause of the cerebral symptoms.
(JAMA 1982;247:2005-2007)
Author Affiliations
USN; USN; USN
From the Departments of Neurology (Drs Sunder and Vengrow) and Pediatrics (Drs Sunder and Balsam), National Naval Medical Center, and the Departments of Neurology (Dr Sunder) and Pediatrics (Drs Sunder and Balsam), Uniformed Services University of the Health Sciences, Bethesda, Md.
Footnotes
The views expressed herein are those of the authors and should not be construed as official or as necessarily reflecting the views of the National Naval Medical Center, the Uniformed Services University of the Health Sciences, or the Navy Medical Department.
Reprint requests to Department of Neurology, National Medical Center, Bethesda, MD 20814 (Dr Sunder).
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