This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Paul T. Williams, MS; Peter D. Wood, DSc; William L. Haskell, PhD; Karen Vranizan, MA

JAMA. 1982;247(19):2674-2679.

Abstract
Eighty-one healthy, sedentary men aged 30 to 55 years were randomly assigned to supervised running (n=48) or to sedentary control groups (n=33) and followed up in a one-year trial. Measurements of plasma lipoproteins, fitness, and percent body fat were made at three-month intervals. Results and conclusions from this study are (1) that cross-sectional studies of lipoprotein concentrations in exercisers may be biased by a self-selection effect, since study participants with initially higher high-density lipoprotein cholesterol (HDL-C) and lower triglyceride concentrations were more easily persuaded to run more miles; (2) that plasma concentrations of HDL-C and low-density lipoprotein cholesterol (LDL-C) generally did not begin to change until a threshold exercise level (ten miles run per week) was maintained for at least nine months; and (3) that fitness increased and percent body fat decreased sooner and at lower exercise levels than required for HDL-C and LDL-C concentration changes.

(JAMA 1982;247:2674-2679)

Author Affiliations
From the Stanford Heart Disease Prevention Program, Stanford University School of Medicine, Stanford, Calif.

Footnotes
Reprint requests to Stanford Heart Disease Prevention Program, 730 Welch Rd, Suite B, Palo Alto, CA 94304 (Mr Williams).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Prospective Epidemiological Cohort Study of Reduced Risk for Incident Cataract with Vigorous Physical Activity and Cardiorespiratory Fitness during a 7-Year Follow-up
Williams
IOVS 2009;50:95-100.
ABSTRACT | FULL TEXT  

Lipid metabolism response to a single, prolonged bout of endurance exercise in healthy young men
Magkos et al.
Am. J. Physiol. Endocrinol. Metab. 2006;290:E355-E362.
ABSTRACT | FULL TEXT  

Concordant lipoprotein and weight responses to dietary fat change in identical twins with divergent exercise levels 1
Williams et al.
Am. J. Clin. Nutr. 2005;82:181-187.
ABSTRACT | FULL TEXT  

Effects of the Amount and Intensity of Exercise on Plasma Lipoproteins
Kraus et al.
NEJM 2002;347:1483-1492.
ABSTRACT | FULL TEXT  

Does Exercise Increase HDL Cholesterol in Those Who Need It the Most?
Thompson and Rader
Arterioscler. Thromb. Vasc. Bio. 2001;21:1097-1098.
FULL TEXT  

Relationships of Heart Disease Risk Factors to Exercise Quantity and Intensity
Williams
Arch Intern Med 1998;158:237-245.
ABSTRACT | FULL TEXT  

Total, LDL, and HDL Cholesterol Decrease With Age in Older Men and Women : The Rancho Bernardo Study 1984–1994
Ferrara et al.
Circulation 1997;96:37-43.
ABSTRACT | FULL TEXT  

Relationship of Distance Run per Week to Coronary Heart Disease Risk Factors in 8283 Male Runners: The National Runners' Health Study
Williams
Arch Intern Med 1997;157:191-198.
ABSTRACT  

Training intensity, blood lipids, and apolipoproteins in men with high cholesterol
Crouse et al.
J. Appl. Physiol. 1997;82:270-277.
ABSTRACT | FULL TEXT  

Reported Exercise Patterns and their Relationship to Lipid Levels among Healthy Older Adults
Fitzgerald et al.
Research on Aging 1996;18:477-493.
ABSTRACT  

High-Density Lipoprotein Cholesterol and Other Risk Factors for Coronary Heart Disease in Female Runners
Williams
NEJM 1996;334:1298-1304.
ABSTRACT | FULL TEXT  

Miles Run per Week and High-Density Lipoprotein Cholesterol Levels in Healthy, Middle-aged Men: A Dose-Response Relationship
Kokkinos et al.
Arch Intern Med 1995;155:415-420.
ABSTRACT  

Exercise Training for Very Elderly People
Leveille et al.
NEJM 1994;331:1237-1238.
FULL TEXT  

Young Long Distance Runners: Physiological and Psychological Characteristics
Nudel et al.
CLIN PEDIATR 1989;28:500-505.
ABSTRACT  

Exercise in Cardiovascular Disease
Dubbert et al.
Behav Modif 1987;11:329-347.
ABSTRACT  

High-Density Lipoprotein Cholesterol Measurements: A Help or Hindrance in Practical Clinical Medicine?
Superko et al.
JAMA 1986;256:2714-2717.
ABSTRACT  

Zinc Ingestion and Lipoprotein Values in Sedentary and Endurance-Trained Men
Crouse et al.
JAMA 1984;252:785-787.
ABSTRACT