This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Alfred J. Saah, MD; Thomas R. Koch, PhD; George L. Drusano, MD

JAMA. 1982;247(2):205-206.

Abstract
Cefoxitin sodium has been found to act like creatinine in assays for creatinine used by many hospitals. Our in vitro results show that cefoxitin causes an apparent rise in the serum creatinine level; the magnitude of the increase depends on the assay method and the concentration of cefoxitin. Results varied from 1.5 to more than 8.5 times the normal serum creatinine level. Published data from studies of human volunteers show the same effect. In patients with normal renal function, the serum creatinine test is reliable two to four hours following cefoxitin infusion and in mild to moderate renal failure (glomerular filtration rate greater than 30 mL/min), six to eight hours. In severe renal failure, the serum creatinine determination is unreliable. Measurement of urinary creatinine employs similar assays, thus making estimation of creatinine clearance unreliable when the patient is receiving cefoxitin.

(JAMA 1982;247:205-206)

Author Affiliations
From the Division of Infectious Diseases (Drs Saah and Drusano) and the Department of Pathology (Dr Koch), the University of Maryland School of Medicine and Hospital, Baltimore. Dr Saah is now with the Epidemiology and Biometry Branch, National Institute of Allergy and Infectious Diseases, Bethesda, Md.

Footnotes
Reprint requests to Division of Infectious Diseases, University of Maryland School of Medicine and Hospital, 29 S Greene St, Baltimore, MD 21201 (Dr Drusano).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Recommendations for Improving Serum Creatinine Measurement: A Report from the Laboratory Working Group of the National Kidney Disease Education Program
Myers et al.
Clin. Chem. 2006;52:5-18.
ABSTRACT | FULL TEXT  

Assessment and Recommendations on Factors Contributing to Preanalytical Variability of Urinary Pyridinoline and Deoxypyridinoline
Vesper et al.
Clin. Chem. 2002;48:220-235.
ABSTRACT | FULL TEXT  

The Decreased Serum Urea Nitrogen-Creatinine Ratio
Jurado and Mattix
Arch Intern Med 1998;158:2509-2511.
ABSTRACT | FULL TEXT  

False Elevation in Serum Creatinine Levels
Herrington et al.
JAMA 1984;252:2962-2962.
ABSTRACT