This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Maurice A. Mufson, MD; Gretchen Oley, MD; Dallas Hughey

JAMA. 1982;248(12):1486-1489.

Abstract
To assess the importance of bacteremic pneumococcal disease among the population of one "average" American community, we studied all hospitalized patients who had Streptococcus pneumoniae isolated from blood, CSF, pleural fluid, or ascitic fluid during the years 1978 through 1981 in Huntington, WVa, and environs. Seventeen patients were children younger than 13 years, and 71 were adults. The case fatality rate from bacteremic pneumococcal disease among adults was 30%, and among children it was 6%. It was much higher (88%) in adults older than 50 years with extrapulmonary disease. Approximately four fifths of the typed isolates from adults or children were types included in the current vaccine. Eighty-nine percent of the adults who died of pneumococcal infection had been candidates for pneumococcal vaccine, but only one patient had received vaccine, just before becoming ill with pneumococcal disease. These data provide a basis for widespread use of pneumococcal vaccine in high-risk groups.

(JAMA 1982;248:1486-1489)

Author Affiliations
From the Department of Medicine, Marshall University School of Medicine (Drs Mufson and Oley), and the Veterans Administration Medical Center (Dr Mufson and Ms Hughey), Huntington, WVa.

Footnotes
Reprint requests to the Department of Medicine, Marshall University School of Medicine, Huntington, WV 25701 (Dr Mufson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Pneumococcal Peritonitis in Adult Patients: Report of 64 Cases With Special Reference to Emergence of Antibiotic Resistance
Capdevila et al.
Arch Intern Med 2001;161:1742-1748.
ABSTRACT | FULL TEXT  

Risk Factors for 30-Day Mortality in Elderly Patients With Lower Respiratory Tract Infection: Community-Based Study
Houston et al.
Arch Intern Med 1997;157:2190-2195.
ABSTRACT  

Prognosis and Outcomes of Patients With Community-Acquired Pneumonia: A Meta-analysis
Fine et al.
JAMA 1996;275:134-141.
ABSTRACT  

The Prevalence of Drug-Resistant Streptococcus pneumoniae In Atlanta
Hofmann et al.
NEJM 1995;333:481-486.
ABSTRACT | FULL TEXT  

Epidemiology of Invasive Childhood Pneumococcal Infections in Israel
Dagan et al.
JAMA 1992;268:3328-3332.
ABSTRACT  

Predicting Death in Patients Hospitalized for Community-acquired Pneumonia
Farr et al.
ANN INTERN MED 1991;115:428-436.
ABSTRACT  

Invasive Group B Streptococcal Disease in Adults: A Population-Based Study in Metropolitan Atlanta
Schwartz et al.
JAMA 1991;266:1112-1114.
ABSTRACT  

Hospital-Based Pneumococcal Immunization: Epidemiologic Rationale From the Shenandoah Study
Fedson et al.
JAMA 1990;264:1117-1122.
ABSTRACT  

Pneumococcal Bacteremia in Charleston County, South Carolina: A Decade Later
Breiman et al.
Arch Intern Med 1990;150:1401-1405.
ABSTRACT  

Invasive Pneumococcal Disease in an Alaska Native Population, 1980 Through 1986
Davidson et al.
JAMA 1989;261:715-718.
ABSTRACT  

The Clinical Effectiveness of Pneumococcal Vaccine in the Elderly
SIMS et al.
ANN INTERN MED 1988;108:653-657.
ABSTRACT  

Immunization Policies and Vaccine Coverage Among Adults: The Risk for Missed Opportunities
WILLIAMS et al.
ANN INTERN MED 1988;108:616-625.
ABSTRACT  

Risk Factors for Acquiring Pneumococcal Infections
Lipsky et al.
Arch Intern Med 1986;146:2179-2185.
ABSTRACT  

Cost Effectiveness of Vaccination Against Pneumococcal Pneumonia: An Update
SISK and RIEGELMAN
ANN INTERN MED 1986;104:79-86.
ABSTRACT  

Pneumococcal Vaccine and Patients with Chronic Lung Disease
WILLIAMS and MOSER
ANN INTERN MED 1986;104:106-109.
ABSTRACT  

Pneumococcal Vaccine: The Evidence Mounts
LAFORCE and EICKHOFF
ANN INTERN MED 1986;104:110-112.
ABSTRACT  

A Controlled Evaluation of the Protective Efficacy of Pneumococcal Vaccine for Patients at High Risk of Serious Pneumococcal Infections
SHAPIRO and CLEMENS
ANN INTERN MED 1984;101:325-330.
ABSTRACT  

Pneumococcal Vaccine Strategy: Feasibility of a Vaccination Program Directed at Hospitalized and Ambulatory Patients
Magnussen et al.
Arch Intern Med 1984;144:1755-1757.
ABSTRACT  

Influenza and Pneumococcal Immunization in Medical Clinics, 1978-1980
Ratner and Fedson
Arch Intern Med 1983;143:2066-2069.
ABSTRACT  

Pneumococcal Vaccine in the Hospital: Improved Use and Implications for High-Risk Patients
Klein and Adachi
Arch Intern Med 1983;143:1878-1881.
ABSTRACT  

Previous Hospital Care and Pneumococcal Bacteremia: Importance for Pneumococcal Immunization
Fedson and Chiarello
Arch Intern Med 1983;143:885-889.
ABSTRACT  

Pneumococcal Vaccine for the `Healthy Elderly'?-Reply
Mufson
JAMA 1983;249:1567-1567.
ABSTRACT  

Pneumococcal Vaccine for the `Healthy Elderly'?
Mann
JAMA 1983;249:1566-1567.
ABSTRACT