This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (41)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

II. Results of Long-term Therapy

Veterans Administration Cooperative Study Group on Antihypertensive Agents

JAMA. 1982;248(16):2004-2011.

Abstract
As described in the preceding communication, either propranolol hydrochloride or hydrochlorothiazide were randomly allocated in a doubleblind manner to 683 patients with initial diastolic BP in the range of 95 to 114 mm Hg. Of this number, 394 entered the long-term treatment phase. During the subsequent 12 months of long-term treatment, hydrochlorothiazide was more effective than propranolol in controlling BP (mean reductions, —17.5/ —13.1 mm Hg with hydrochlorothiazide compared with —8.3/—11.3 with propranolol. After treatment with hydrochlorothiazide, a greater percentage of patients achieved the goal diastolic BP of less than 90 mm Hg (65.5% compared with 52.8% taking propranolol). Also during treatment, fewer patients receiving hydrochlorothiazide required termination as compared with those receiving propranolol; comparative dosage requirements were lower; additional titration during long-term treatment was required less often, and BP remained lower after withdrawal of the active drugs. However, biochemical abnormalities were greater with hydrochlorothiazide. Although not statistically significant, the antihypertensive effects of hydrochlorothiazide were greater in blacks than in whites. Whites, on the other hand, had a greater response to propranolol than blacks, although it was still less than the response of the whites to hydrochlorothiazide.

(JAMA 1982;248:2004-2011)

Author Affiliations
From the Cooperative Studies Program, Medical Research Service of the Veterans Administration, Washington, DC.

Footnotes
Reprint requests to the Veterans Administration Medical Center, 50 Irving St NW, Washington, DC 20422 (Edward D. Freis, MD).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

{beta}-Adrenergic Antagonists in Hypertension: A Review of the Evidence
Warmack et al.
The Annals of Pharmacotherapy 2009;43:2031-2043.
ABSTRACT | FULL TEXT  

Relation of Beta-Blocker-Induced Heart Rate Lowering and Cardioprotection in Hypertension
Bangalore et al.
J Am Coll Cardiol 2008;52:1482-1489.
ABSTRACT | FULL TEXT  

Ethnic Differences in Cardiovascular Drug Response: Potential Contribution of Pharmacogenetics
Johnson
Circulation 2008;118:1383-1393.
FULL TEXT  

Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension1
Dietz et al.
Journal of Renin-Angiotensin-Aldosterone System 2008;9:163-175.
ABSTRACT  

Re-examining the efficacy of {beta}-blockers for the treatment of hypertension: a meta-analysis
Khan and McAlister
CMAJ 2006;174:1737-1742.
ABSTRACT | FULL TEXT  

Systolic Blood Pressure, Diastolic Blood Pressure, and Pulse Pressure as Predictors of Risk for Congestive Heart Failure in the Framingham Heart Study
Haider et al.
ANN INTERN MED 2003;138:10-16.
ABSTRACT | FULL TEXT  

Systematic review of antihypertensive therapies: Does the evidence assist in choosing a first-line drug?
Wright et al.
CMAJ 1999;161:25-32.
ABSTRACT | FULL TEXT  

Fixed Low-Dose Drug Combination for the Treatment of Hypertension
Chrysant
Arch Fam Med 1998;7:370-376.
ABSTRACT | FULL TEXT  

Trends in Medication Choices for Hypertension in the Elderly : The Decline of the Thiazides
Monane et al.
Hypertension 1995;25:1045-1051.
ABSTRACT | FULL TEXT  

Sexual Dysfunction With Antihypertensive Drugs
Prisant et al.
Arch Intern Med 1994;154:730-736.
ABSTRACT  

{beta}-Blockers, Dyslipidemia, and Coronary Artery Disease: A Reassessment
Burris
Arch Intern Med 1993;153:2085-2092.
ABSTRACT  

Low Levels of High-Density Lipoprotein Cholesterol (Hypoalphalipoproteinemia) An Approach to Management
Rosenson
Arch Intern Med 1993;153:1528-1538.
ABSTRACT  

Single-Drug Therapy for Hypertension in Men -- A Comparison of Six Antihypertensive Agents with Placebo
Materson et al.
NEJM 1993;328:914-921.
ABSTRACT | FULL TEXT  

National Education Programs Working Group Report on the Management of Patients with Hypertension and High Blood Cholesterol
Working Group on Management of Patients with Hyper
ANN INTERN MED 1991;114:224-237.
ABSTRACT  

Diuretics--Current Issues and Updates
Carasiti
Journal of Pharmacy Practice 1990;3:295-304.
 

Critique of the Clinical Importance of Diurectic-Induced Hypokalemia and Elevated Cholesterol Level
FREIS
Arch Intern Med 1989;149:2640-2648.
ABSTRACT  

Comparison of the Antihypertensive Effects of Betaxolol and Chlorthalidone as Monotherapy and in Combination
Burris et al.
Arch Intern Med 1989;149:2437-2441.
ABSTRACT  

{beta}-Blockers and Primary Prevention of Coronary Heart Disease in Patients With High Blood Pressure
Psaty et al.
JAMA 1989;261:2087-2094.
ABSTRACT  

Cigarette Smoking Interferes With Treatment of Hypertension
Materson et al.
Arch Intern Med 1988;148:2116-2119.
ABSTRACT  

The Effects of Antihypertensive Agents on Serum Lipids and Lipoproteins
Lardinois and Neuman
Arch Intern Med 1988;148:1280-1288.
ABSTRACT  

A Comparison of Verapamil and Propranolol for the Initial Treatment of Hypertension: Racial Differences in Response
Cubeddu et al.
JAMA 1986;256:2214-2221.
ABSTRACT  

Thiazides Do Not Cause Long-term Increases in Serum Lipid Concentrations
Burris and Freis
Arch Intern Med 1985;145:2264-2266.
ABSTRACT  

Antihypertensive Therapy and Lipids: Evidence, Mechanisms, and Implications
Weinberger
Arch Intern Med 1985;145:1102-1105.
ABSTRACT  

Transdermal Administration of Clonidine for Treatment of High BP
Weber et al.
Arch Intern Med 1984;144:1211-1213.
ABSTRACT  

Mild Hypertension
Burris
Arch Intern Med 1983;143:2015-2015.
ABSTRACT  

Metabolic Consequences of Antihypertensive Therapy
FLAMENBAUM
ANN INTERN MED 1983;98:875-880.
ABSTRACT