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Howard R. Terebelo, DO; Raymond L. McCue, MD; Merle S. Lenneville, MD

JAMA. 1982;248(16):2028-2029.

Abstract
Prolonged tissue oxygenation and maintenance of intravascular oncotic pressure are severely impaired with the absence of an effective RBC mass. We recently encountered a patient with a nondetectable hematocrit value (0%) attributed to Clostridium perfringens hemolysis. The patient maintained normal BP, tissue oxygenation, and mentation and survived longer than four hours, despite ineffective transfusion therapy. Plasma free hemoglobin was responsible for the preservation of tissue oxygenation, intravascular oncotic pressure, and pH. Existing studies in animals support stroma-free hemoglobin as an effective blood product in humans.

(JAMA 1982;248:2028-2029)

Author Affiliations
From the Hematology Service (Dr Terebelo), Obstetrics and Gynecology Service (Dr McCue), and Pathology Department (Dr Lenneville), Walter Reed Army Medical Center, Washington, DC.

Footnotes
The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

Reprint requests to Hematology Service, Walter Reed Army Medical Center, Washington, DC 20012 (Dr Terebelo).

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