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The Value of Crossmatch Procedures for Donor Selection

Thomas Hecht, MD; Jeffrey L. Wolf, MD; Laurene Mraz; Edward P. Scott, MD; Lawrence D. Petz, MD

JAMA. 1982;248(18):2301-2303.

Abstract
A 51-year-old patient with acute myelogenous leukemia, who was alloimmunized to platelets, failed to show adequate platelet increments after receiving transfusions of HLA grade A-identical platelets. Only platelets from an HLA grade B-matching donor gave high increments. Several crossmatching procedures were used to select platelet donors. A correlation was seen between in vitro tests and in vivo response. HLA typing has limitations in the selection of platelet-compatible donors.

(JAMA 1982;248:2301-2303)

Author Affiliations
From the Department of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, Calif.

Footnotes
Reprint requests to Department of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010 (Dr Hecht).

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