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Priscilla Ann Gilman, MD; Neil A. Holtzman, MD

JAMA. 1982;248(4):467-468.

Abstract
Acute lymphoblastic leukemia developed in a girl with Wilson's disease after 37 months of high-dose penicillamine therapy. We postulate that penicillamine-induced alterations in host immunity may cause a predisposition to certain malignancies, similar to that which occurs in other acquired or inherited immunodeficiency states.

(JAMA 1982;248:467-468)

Author Affiliations
From the Clinical Epidemiology Branch, National Cancer Institute. National Institutes of Health, Bethesda, Md; and the Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore (Drs Gilman and Holtzman).

Footnotes
Reprint requests to Clinical Epidemiology Branch, National Cancer Institute, 5A21 Landow Bldg, National Institutes of Health, Bethesda, MD 20205 (Dr Gilman).

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