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Thomas J. Halpin, MD, MPH; Francis J. Holtzhauer, MS; Robert J. Campbell, MS; Lois J. Hall; Adolfo Correa-Villaseñor, MD, MPH; Richard Lanese, PhD; Janet Rice, PhD; Eugene S. Hurwitz, MD

JAMA. 1982;248(6):687-691.

Abstract
Ninety-seven Reye's syndrome (RS) cases in Ohio children with onsets from December 1978 through March 1980 were studied for medication use during their pre-RS illness. They were matched with 156 control subjects for age, race, sex, geographic location, time, and type of illness. Only the use of aspirin was reported by significantly more cases (97%, 94/97) than controls (71%, 110/156) during the pre-RS matched illness. Using a multiple logistic model to control for the presence of fever, headache, and sore throat statistically, the difference in aspirin use remained significant. Conversely, fewer cases (16%) took medications containing acetaminophen than controls (33%). In 87% of the cases receiving aspirin, their maximum daily dosage did not exceed recommended levels, but their doses were higher than those of controls receiving aspirin. No relationship was found between dosage and stage of RS encephalopathy.

(JAMA 1982;248:687-691)

Author Affiliations
From the Bureau of Preventive Medicine, Ohio Department of Health, Columbus (Dr Halpin, Messrs Holtzhauer and Campbell, and Ms Hall); the School of Preventive Medicine, Ohio State University, Columbus (Drs Lanese and Rice); and the Centers for Disease Control, Atlanta (Drs Correa-Villaseñor and Hurwitz). Dr Correa-Villaseñor is now with The Johns Hopkins School of Hygiene and Public Health, Baltimore.

Footnotes
Reprint requests to the Bureau of Preventive Medicine, Ohio Department of Health, 246 N High St, PO Box 118, Columbus, OH 43216 (Dr Halpin).

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