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Milton B. Scharf, PhD; Jeffrey S. Lobel, MD; Elsy Caldwell, MD, MPH; Bruce F. Cameron, MD, PhD; Milton Kramer, MD; Jane De Marchis; Charles Paine

JAMA. 1983;249(13):1753-1755.

Abstract
The sleep of two patients with sickle cell disease was punctuated by periods with notably reduced arterial O₂ saturation despite simultaneous normal respiratory rates. The O₂ levels returned to baseline during intermittent wakefulness. Gas exchange patterns during sleep may contribute to the morbidity of sickle cell disease.

(JAMA 1983;249:1753-1755)

Author Affiliations
From the Sleep Disorders Center, University Hospital, the Department of Psychiatry (Drs Scharf and Kramer and Ms De Marchis), and the Department of Medicine (Drs Lobel, Caldwell, and Cameron), University of Cincinnati School of Medicine; and the Cincinnati Comprehensive Sickle Cell Center, Children's Hospital Research Foundation (Drs Lobel, Caldwell, and Cameron and Mr Paine).

Footnotes
Reprint requests to the Sleep Disorders Center, University Hospital, Mont Reid Pavilion, Room 23, Cincinnati, OH 45267 (Dr Scharf).

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ABSTRACT