Physical fitness and subsequent myocardial infarction in healthy workers
R. K. Peters, L. D. Cady Jr, D. P. Bischoff, L. Bernstein and M. C. Pike
Physical work capacity (PWC), a measure of physical fitness, was assessed
by bicycle ergometry on 2,779 healthy men younger than 55 years who were
subsequently followed up for an average of 4.8 years for symptomatic
myocardial infarction (MI). There were 36 MIs. The relative risk (RR) of MI
for below median PWC, adjusted for conventional risk factors for heart
disease, was 2.2 (95% confidence limits, 1.1 and 4.7). This increased risk
appeared to be limited to men with certain other risk factors present
simultaneously: above-median cholesterol level, smoking, above-median
systolic BP, or a combination of these. Among men with at least two of
these factors, the adjusted RR for below-median PWC was 6.6 (95% confidence
limits, 2.3 and 27.8). Poor physical fitness may be an important risk
factor for heart disease, especially when conventional risk factors are
also present.
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