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Optimal Sampling Frequency

Michael L. Fisher, MD; Nathan H. Carliner, MD; Lewis C. Becker, MD; Robert W. Peters, MD; Gary D. Plotnick, MD

JAMA. 1983;249(3):393-394.

Abstract
To document optimal sampling frequency, we reviewed creatine kinase (CK) myocardial specific isoenzyme (CKMB) results in 314 patients with suspected acute myocardial infarction (MI). In 127 patients with elevated CK/CKMB, peak CK observed using all samples (every four-hour [Q4hr] method) was compared with results that would have been obtained had samples been taken on admission and either twice daily (every 12-hour [Q12hr] method) or once daily (every 24-hour [024hr] method). Although average peak CK was statistically different (Q4hr>Q12hr>Q24hr), major underestimation of peak CK (500 units/L) was uncommon (3%) using the Q12hr method, suggesting that Q12hr sampling is a practical, cost-effective approach for patients with suspected acute MI.

(JAMA 1983;249:393-394)

Author Affiliations
From Veterans Administration Medical Center, University of Maryland School of Medicine (Drs Fisher, Carliner, Peters, and Plotnick); and The Johns Hopkins Medical Institutions (Dr Becker), Baltimore.

Footnotes
Reprint requests to VA Medical Center, 3900 Loch Raven Blvd, Baltimore, MD 21218 (Dr Fisher).

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