Antibody response following measles-mumps-rubella vaccine under conditions of customary use
P. A. Brunell, K. Weigle, M. D. Murphy, Z. Shehab and E. Cobb
A study of 301 children who had been immunized two to 19 months previously
with measles, mumps, and rubella (MMR) vaccine at 36 different sites in San
Antonio, Tex, including physicians' offices and clinics, revealed that
99.7% had antibody against rubella and 98.3% had antibody against measles
and mumps. None of the 49 infants who were tested prior to receipt of MMR
vaccine had antibody against any of these viruses, indicating that the
antibody found after immunization was unlikely to be due to false-positive
results. The lack of antibody in these infants confirmed that there had not
been a significant number of cases of these diseases that could contribute
to the high frequency of antibody found after immunization. A single dose
of MMR vaccine administered under customary conditions appears to be an
effective method of conferring immunity against these diseases.
