Cervical Chlamydia trachomatis and mycoplasmal infections in pregnancy. Epidemiology and outcomes

H. R. Harrison, E. R. Alexander, L. Weinstein, M. Lewis, M. Nash and D. A. Sim

In a prospective study of chlamydial and mycoplasmal infections in pregnancy, Chlamydia trachomatis occurred in 8.0%, Mycoplasma hominis in 23.5%, and Ureaplasma urealyticum in 72.3% of 1,365 enrollees. By multivariate analysis, C trachomatis was correlated with lower socioeconomic status, age 23 years or younger, and 12 years or less of schooling. Ureaplasma urealyticum was correlated with age 23 years or younger and lower socioeconomic status. Mycoplasma hominis was correlated with more than one recent sexual partner, first intercourse at age 17 years or younger, and higher socioeconomic status. These cervical infections did not predict low birth weight, abortion, stillbirth, prematurity, or premature rupture of membranes. Only M hominis predicted endometritis/fever after vaginal delivery (relative risk, 7.3). IgM-seropositive C trachomatis-infected women had more low-birth-weight infants and more premature rupture of membranes than either IgM-negative C trachomatis-infected women or C trachomatis culture-negative women. Thus, only certain subgroups of infected women may experience adverse pregnancy outcomes.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Regulation of surfactant protein D in the mouse female reproductive tract in vivo
Oberley et al.
Mol Hum Reprod 2007;13:863-868.
ABSTRACT | FULL TEXT  

Pregnancy outcomes in women infected with Chlamydia trachomatis: a population-based cohort study in Washington State
Blas et al.
Sex. Transm. Infect. 2007;83:314-318.
ABSTRACT | FULL TEXT  

Association between Preterm Birth and Vaginal Colonization by Mycoplasmas in Early Pregnancy
Kataoka et al.
J. Clin. Microbiol. 2006;44:51-55.
ABSTRACT | FULL TEXT  

Sexually transmitted infections in pregnancy: prevalence, impact on pregnancy outcomes, and approach to treatment in developing countries
Mullick et al.
Sex. Transm. Infect. 2005;81:294-302.
ABSTRACT | FULL TEXT  

Serum C-reactive Protein and Chlamydia trachomatis Antibodies in Preterm Delivery
Karinen et al.
Obstet Gynecol 2005;106:73-80.
ABSTRACT | FULL TEXT  

Surfactant protein D is present in the human female reproductive tract and inhibits Chlamydia trachomatis infection
Oberley et al.
Mol Hum Reprod 2004;10:861-870.
ABSTRACT | FULL TEXT  

Randomized Clinical Trial of Extended Spectrum Antibiotic Prophylaxis With Coverage for Ureaplasma urealyticum to Reduce Post-Cesarean Delivery Endometritis
Andrews et al.
Obstet Gynecol 2003;101:1183-1189.
ABSTRACT | FULL TEXT  

Infection-related Preterm Birth: A Review of the Evidence
Guinn and Gibbs
NeoReviews 2002;3:e86-96.
FULL TEXT  

A Murine Model for the Study of Chlamydia trachomatis Genital Infections during Pregnancy
Pal et al.
Infect. Immun. 1999;67:2607-2610.
ABSTRACT | FULL TEXT  

Serological Tests for Chlamydia trachomatis Infections
Numazaki; and Black
Clin. Microbiol. Rev. 1998;11:228-229.
FULL TEXT  

A School-based Chlamydia Control Program Using DNA Amplification Technology
Cohen et al.
Pediatrics 1998;101 :e1-e1.
ABSTRACT | FULL TEXT  

Self-Esteem, Problem Solving, and Sexual Risk Behavior among Women with and without Chlamydia
Abel et al.
Clin Nurs Res 1994;3:353-370.
ABSTRACT  

Early Detection and Treatment of Sexually Transmitted Disease in Pregnant Adolescents of Low Socioeconomic Status
Matson et al.
CLIN PEDIATR 1993;32:609-612.
ABSTRACT