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The Collaborative Lipid Research Clinics Family Study

John A. Morrison, PhD; Kadambari Namboodiri, PhD; Philip Green, PhD; Jeanne Martin, MPH; Charles J. Glueck, MD

JAMA. 1983;250(14):1860-1868.

Abstract
We examined the hypothesis that familial aggregation of lipids and lipoproteins facilitates within-family identification and hyperlipoproteinemia. We studied 841 offspring and 1,236 siblings of normocholesterolemic probands, 833 offspring and 1,194 siblings of hypercholesterolemic probands, 806 offspring and 1,099 siblings of normotriglyceridemic probands, and 877 offspring and 1,108 siblings of hypertriglyceridemic probands in the Lipid Research Clinics Collaborative Family Study Program. As the categorization of probands' hypercholesterolemia or hypertriglyceridemia increased from sporadic, to persistent, to severe, the percentage of hypercholesterolemic or hypertriglyceridemic offspring and siblings increased. Close sibling and parent-offspring lipid and lipoprotein risk factor associations in hypercholesterolemic and hypertriglyceridemic family units during and after the period of shared common-household environment facilitate within-family identification of dyslipoproteinemia and suggest potential sharing of coronary heart disease risk.

(JAMA 1983;250:1860-1868)

Author Affiliations
From the Lipid Research Clinic, General Clinical Research Center, the Clinical Information Data Management and Analysis System Center, and the Department of Internal Medicine, University of Cincinnati College of Medicine (Drs Morrison and Glueck); and the Central Patient Registry and Coordinating Center, Lipid Research Clinics Program, Department of Biostatistics, University of North Carolina, Chapel Hill (Drs Namboodiri and Green and Ms Martin).

Footnotes
Reprint requests to Lipid Metabolism—Atherogenesis Branch, Federal Bldg 401, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20205 (Basil M. Rifkind, MD).

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