You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT JAMA
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 250 No. 15, October 21, 1983 TABLE OF CONTENTS
  JAMA
  •  Online Features
  ORIGINAL CONTRIBUTIONS
 This Article
 •References
 •Full text PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in JAMA
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

The Use of Imipramine in Depressed Patients With Congestive Heart Failure

Alexander H. Glassman, MD; Lynne L. Johnson, MD; Elsa-Grace V. Giardina, MD; B. Timothy Walsh, MD; Steven P. Roose, MD; Thomas B. Cooper; J. Thomas Bigger, Jr, MD

JAMA. 1983;250(15):1997-2001.


Abstract

Previous studies of left ventricular performance (LVP) in depressed patients receiving tricyclic antidepressants have been performed on patients without severe heart disease. This study reports the effect of imipramine hydrochloride on LVP, assessed by radionuclide angiography, in a group of depressed patients with notable preexisting left ventricular dysfunction. Ejection fraction was measured at rest by first-pass radionuclide angiography before and after treatment with imipramine. Ejection fraction was unchanged during treatment, but seven of 15 patients experienced orthostatic hypotension of such severity that administration of the drug had to be discontinued. Plasma concentrations of the drug were essentially twice those usually seen. It is important to appreciate that although imipramine does not further impair resting LVP, this does not mean it is without risk. The physician must watch carefully for orthostatic hypotension when using imipramine in depressed patients with impaired LVP.

(JAMA 1983;250:1997-2001)



Author Affiliations

From the Departments of Psychiatry (Drs Glassman, Walsh, and Cooper), Medicine (Drs Johnson, Giardina, and Bigger), and Pharmacology (Dr Bigger), College of Physicians and Surgeons, Columbia University; and The New York State Psychiatric Institute (Drs Glassman, Walsh, Roose, and Cooper), New York.


Footnotes

Reprint requests to The New York State Psychiatric Institute, 722 W 168th St, New York, NY 10032 (Dr Glassman).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Management of Depression in Patients with Comorbid Cardiovascular Disease
Nelson and Abu-Shanab
Journal of Pharmacy Practice 2001;14:526-539.
ABSTRACT  

Drug-induced heart failure
Feenstra et al.
J Am Coll Cardiol 1999;33:1152-1162.
ABSTRACT | FULL TEXT  

Cardiovascular Effects of Fluoxetine in Depressed Patients With Heart Disease
Roose et al.
Am. J. Psychiatry 1998;155:660-665.
ABSTRACT | FULL TEXT  

Antidepressant drugs and the cardiovascular system: a comparison of tricylics and selective serotonin reuptake inhibitors and their relevance for the treatment of psychiatric patients with cardiovascular problems
Coupland et al.
J Psychopharmacol 1997;11:83-92.
 

Evaluation of Myocardial Cell Damage by In-111-Monoclonal Antimyosin Antibodies in Patients Under Chronic Tricyclic Antidepressant Drug Treatment
Marti et al.
Circulation 1995;91:1619-1623.
ABSTRACT | FULL TEXT  

Tricyclic Antidepressants in the Intensive Care Unit
Dec and Stern
J Intensive Care Med 1990;5:69-81.
ABSTRACT  

Assessment and Treatment of Affective Illness in the Elderly
Jenike
J Geriatr Psychiatry Neurol 1988;1:89-107.
 

Tricyclic Antidepressants in Depressed Patients With Cardiac Conduction Disease
Roose et al.
Arch Gen Psychiatry 1987;44:273-275.
ABSTRACT  

Psychiatric Consultation to Inpatients With 'Early-Onset' Type I Diabetes Mellitus in a University Hospital
Popkin and Callies
Arch Gen Psychiatry 1987;44:169-171.
ABSTRACT  

Nortriptyline in Depressed Patients With Left Ventricular Impairment
Roose et al.
JAMA 1986;256:3253-3257.
ABSTRACT  

Cardiovascular Effects of Polycyclic Antidepressants
Mahapatra et al.
ANGIOLOGY 1986;37:709-717.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1983 American Medical Association. All Rights Reserved.