Aspirin-sulfinpyrazone in prophylaxis of deep venous thrombosis in total hip replacement
R. D. Sautter, E. L. Koch, W. O. Myers, J. R. Ray 3rd, J. J. Mazza, D. E. Larson, H. M. Chen, J. P. Milbauer, P. S. Treuhaft, E. D. Plotka and al. et
In postoperative hip arthroplasty patients, treatment with aspirin and
sulfinpyrazone resulted in a statistically significant reduction of
venographically diagnosed thrombi in the proximal veins of the leg. This
reduction was most apparent in thrombi that involved the iliac vein. When
compared with their placebo-treated counterparts, female patients who
received the active treatment experienced a statistically significant 75%
reduction of thrombosis, compared with a 32% reduction for men that was not
statistically significant. There were no serious adverse effects. Factors
were identified that may influence the result of drug prophylaxis trials in
deep-vein thrombosis.
