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Richard D. Sautter, MD; Edgar L. Koch, MD; William O. Myers, MD; Jefferson R. Ray III, MD; Joseph J. Mazza, MD; David E. Larson, PA-C; Hong-Mo Chen, MD; John P. Milbauer, MD; Paul S. Treuhaft, MD; Edward D. Plotka, PhD; Frederick J. Wenzel, MBA; Gregory Nycz; Willard E. Pierce

JAMA. 1983;250(19):2649-2654.

Abstract
In postoperative hip arthroplasty patients, treatment with aspirin and sulfinpyrazone resulted in a statistically significant reduction of venographically diagnosed thrombi in the proximal veins of the leg. This reduction was most apparent in thrombi that involved the iliac vein. When compared with their placebo-treated counterparts, female patients who received the active treatment experienced a statistically significant 75% reduction of thrombosis, compared with a 32% reduction for men that was not statistically significant. There were no serious adverse effects. Factors were identified that may influence the result of drug prophylaxis trials in deep-vein thrombosis.

(JAMA 1983;250:2649-2654)

Author Affiliations
From the Marshfield (Wis) Clinic and the Marshfield Medical Foundation, Inc (Drs Sautter, Myers, Ray, Chen, Milbauer, Treuhaft, Plotka, and Mazza and Messrs Wenzel, Nycz, and Pierce); the Kenosha (Wis) Memorial Hospital (Dr Koch); and The Arizona Health Plan, Phoenix (Mr Larson).

Footnotes
Reprint requests to Marshfield Medical Foundation, Inc, 510 N St Joseph Ave, Marshfield, WI 54449 (Dr Sautter).

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